Document Detail

High-resolution mapping of the Drosophila fourth chromosome using site-directed terminal deficiencies.
MedLine Citation:
PMID:  15466427     Owner:  NLM     Status:  MEDLINE    
For more than 80 years, the euchromatic right arm of the Drosophila fourth chromosome (101F-102F) has been one of the least genetically accessible regions of the fly genome despite the fact that many important genes reside there. To improve the mapping of genes on the fourth chromosome, we describe a strategy to generate targeted deficiencies and we describe 13 deficiencies that subdivide the 300 kb between the cytological coordinates 102A6 and 102C1 into five discrete regions plus a 200-kb region from 102C1 to 102D6. Together these deficiencies substantially improve the mapping capabilities for mutant loci on the fourth chromosome.
Rui Sousa-Neves; Tamas Lukacsovich; Claudia Mieko Mizutani; John Locke; Lynn Podemski; J Lawrence Marsh
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.     Date:  2004-09-30
Journal Detail:
Title:  Genetics     Volume:  170     ISSN:  0016-6731     ISO Abbreviation:  Genetics     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-05-25     Completed Date:  2006-06-06     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  0374636     Medline TA:  Genetics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  127-38     Citation Subset:  IM    
Department of Developmental and Cell Biology and the Developmental Biology Center, University of California, Irvine, 92697, USA.
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MeSH Terms
Chromosome Aberrations*
Chromosome Mapping*
Drosophila melanogaster / genetics*
Genes, Lethal
Genetic Markers
Mutagenesis, Site-Directed*
Grant Support
Reg. No./Substance:
0/Genetic Markers

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