| High-resolution magnetization-prepared 3D-FLAIR imaging at 7.0 Tesla. | |
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MedLine Citation:
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PMID: 20572143 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the present study is to develop a submillimeter volumetric (three-dimensional) fluid-attenuated inversion recovery sequence at 7T. Implementation of the fluid-attenuated inversion recovery sequence is difficult as increased T(1) weighting from prolonged T(1) constants at 7T dominate the desired T(2) contrast and yield suboptimal signal-to-noise ratio. Magnetization preparation was used to reduce T(1) weighting and improve the T(2) weighting. Also, practical challenges limit the implementation. Long refocusing trains with low flip angles were used to mitigate the specific absorption rate constraints. This resulted in a three-dimensional magnetization preparation fluid-attenuated inversion recovery sequence with 0.8 x 0.8 x 0.8 = 0.5 mm(3) resolution in a clinically acceptable scan time. The contrast-to-noise ratio between gray matter and white matter (contrast-to-noise ratio = signal-to-noise ratio [gray matter] - signal-to-noise ratio [white matter]) increased from 12 +/- 9 without magnetization preparation to 28 +/- 8 with magnetization preparation (n = 12). The signal-to-noise ratio increased for white matter by 13 +/- 6% and for gray matter by 48 +/- 15%. In conclusion, three-dimensional fluid-attenuated inversion recovery with high resolution and full brain coverage is feasible at 7T. Magnetization preparation reduces the T(1) weighting, thereby improving the T(2) weighted contrast and signal-to-noise ratio. |
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Authors:
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Fredy Visser; Jaco J M Zwanenburg; Johannes M Hoogduin; Peter R Luijten |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 64 ISSN: 1522-2594 ISO Abbreviation: Magn Reson Med Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-29 Completed Date: 2010-10-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
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Languages: eng Pagination: 194-202 Citation Subset: IM |
Copyright Information:
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(c) 2010 Wiley-Liss, Inc. |
Affiliation:
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Department of Radiology, University Medical Centre Utrecht, Utrecht, The Netherlands. F.Visser-2@umcutrecht.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Artifacts Brain / radiography* Female Humans Imaging, Three-Dimensional* Magnetics* Male |
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