| High resolution magnetic susceptibility mapping of the substantia nigra in Parkinson's disease. | |
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MedLine Citation:
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PMID: 21987471 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: To determine if tissue magnetic susceptibility is a more direct marker of tissue iron content than other MR markers of iron. This study presents the first quantitative, in vivo measurements of the susceptibility of the substantia nigra in patients with Parkinson's disease. MATERIALS AND METHODS: Nine patients and 11 controls were studied at 7 Tesla. Susceptibility maps were created by inverting the filtered phase maps associated with T2* weighted images. RESULTS: On average, patients showed an increase in susceptibility of the pars compacta compared with controls, which correlates with the predicted increase in brain iron in Parkinson's disease. A rostral-caudal gradient in susceptibility was also observed in controls and patients. CONCLUSION: Susceptibility mapping may provide a new tool for studying the development of Parkinson's disease. J. Magn. Reson. Imaging 2011;. © 2011 Wiley-Liss, Inc. |
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Authors:
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Ashley K Lotfipour; Samuel Wharton; Stefan T Schwarz; V Gontu; Andreas Schäfer; Andrew M Peters; Richard W Bowtell; Dorothee P Auer; Penny A Gowland; Nin P S Bajaj |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-10 |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: - ISSN: 1522-2586 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Wiley-Liss, Inc. |
Affiliation:
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Sir Peter Mansfield Magnetic Resonance Centre, School of Physics and Astronomy, Nottingham, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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