| High-resolution magnetic resonance angiography in the mouse using a nanoparticle blood-pool contrast agent. | |
| | |
MedLine Citation:
|
PMID: 19902507 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
High-resolution magnetic resonance angiography is already a useful tool for studying mouse models of human disease. Magnetic resonance angiography in the mouse is typically performed using time-of-flight contrast. In this work, a new long-circulating blood-pool contrast agent-a liposomal nanoparticle with surface-conjugated gadolinium (SC-Gd liposomes)-was evaluated for use in mouse neurovascular magnetic resonance angiography. A total of 12 mice were imaged. Scan parameters were optimized for both time-of-flight and SC-Gd contrast. Compared to time-of-flight contrast, SC-Gd liposomes (0.08 mmol/kg) enabled improved small-vessel contrast-to-noise ratio, larger field of view, shorter scan time, and imaging of venous structures. For a limited field of view, time-of-flight and SC-Gd were not significantly different; however, SC-Gd provided better contrast-to-noise ratio when the field of view encompassed the whole brain (P < 0.001) or the whole neurovascular axis (P < 0.001). SC-Gd allowed acquisition of high-resolution magnetic resonance angiography (52 x 52 x 100 micrometer(3) or 0.27 nL), with 123% higher (P < 0.001) contrast-to-noise ratio in comparable scan time ( approximately 45 min). Alternatively, SC-Gd liposomes could be used to acquire high-resolution magnetic resonance angiography (0.27 nL) with 32% higher contrast-to-noise ratio (P < 0.001) in 75% shorter scan time (12 min). |
| | |
Authors:
|
Gabriel P Howles; Ketan B Ghaghada; Yi Qi; Srinivasan Mukundan; G Allan Johnson |
Related Documents
:
|
10740177 - Magnetic resonance imaging of the facial nerve in children with idiopathic facial paral... 17663257 - Multi-functional chitosan nanoparticles encapsulating quantum dots and gd-dtpa as imagi... 8495577 - An assessment of gd-dtpa as a ct contrast agent in the renal tract. 3454167 - Balance of t1-weighted images before and after application of a paramagnetic substance ... 21989997 - Predicting response to neoadjuvant chemoradiation therapy in locally advanced rectal ca... 19561247 - Tracheobronchomalacia in infants and children: multidetector ct evaluation. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 62 ISSN: 1522-2594 ISO Abbreviation: Magn Reson Med Publication Date: 2009 Dec |
Date Detail:
|
Created Date: 2009-11-30 Completed Date: 2010-02-22 Revised Date: 2011-08-01 |
Medline Journal Info:
|
Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
|
Languages: eng Pagination: 1447-56 Citation Subset: IM |
Copyright Information:
|
(c) 2009 Wiley-Liss, Inc. |
Affiliation:
|
Center for In Vivo Microscopy, Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cerebral Arteries / anatomy & histology* Contrast Media / chemistry* Gadolinium / chemistry, diagnostic use* Image Enhancement / methods* Liposomes / chemistry Magnetic Resonance Angiography / methods* Male Mice Mice, Inbred C57BL Nanoparticles / chemistry*, diagnostic use* |
| Grant Support | |
ID/Acronym/Agency:
|
P41 RR005959/RR/NCRR NIH HHS; P41 RR005959-19/RR/NCRR NIH HHS; U24 CA092656/CA/NCI NIH HHS; U24 CA092656-09/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Contrast Media; 0/Liposomes; 7440-54-2/Gadolinium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The conserved active site tryptophan of thioredoxin has no effect on its redox properties.
Next Document: Online real-time reconstruction of adaptive TSENSE with commodity CPU/GPU hardware.