| High-resolution computed tomography features of pulmonary chronic graft-versus-host disease following hematopoietic stem cell transplantation: histopathological correlation. | |
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MedLine Citation:
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PMID: 21359937 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE: The purposes of this study were to evaluate the development pattern in patients with multiple episodes of chronic graft-versus-host disease (cGVHD) and to analyze the computed tomography (CT) appearances of the pulmonary parenchymal injury and its relation to treatment response. MATERIALS AND METHODS: CT patterns from 41 episodes of cGVHD (25 patients) were evaluated retrospectively and classified into four groups: group 1, airway involvement; group 2, subpleural consolidation or ground glass opacity (GGO); group 3, peribronchovascular/periseptal GGO or consolidations; group 4, others. We analyzed the changing pattern of the CT appearance during multiple episodes and the relation between this CT pattern and response to treatment. RESULTS: None of the patients showed airway involvement (group 1) and pulmonary parenchymal injury patterns (group 2 and 3) simultaneously in one episode. The group 3 CT pattern was more resistant to treatment than that of group 2 (P < 0.05). The pathological basis of the group 3 CT pattern varied but was characterized by mural incorporation fibrosis. CONCLUSION: Pulmonary cGVHD affected either the airway or pulmonary parenchyma but did not affect both simultaneously in one episode. Of the four patterns, peribronchovascular GGO/consolidations (group 3 CT pattern) was the most resistant to treatment. |
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Authors:
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Noriyo Yanagawa; Fumikazu Sakai; Noriko Kamata; Tsunekazu Hishima; Tamiko Takemura; Kazuteru Ohashi |
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Publication Detail:
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Type: Journal Article Date: 2011-02-27 |
Journal Detail:
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Title: Japanese journal of radiology Volume: 29 ISSN: 1867-108X ISO Abbreviation: Jpn J Radiol Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-03-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101490689 Medline TA: Jpn J Radiol Country: Japan |
Other Details:
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Languages: eng Pagination: 116-28 Citation Subset: IM |
Affiliation:
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Department of Radiology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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