| A high-resolution view of achalasia. | |
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MedLine Citation:
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PMID: 19077727 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: High-resolution manometry (HRM) makes it possible to better evaluate spatial and temporal characteristics of esophageal motor function. This technology is revealing new observations regarding disordered motor function in esophageal diseases. GOAL: The aim of this study was to define the essential features of achalasia using HRM. STUDY: We performed HRM on 27 patients with achalasia, 10 patients with gastroesophageal reflux disease, and 10 controls. Ten 5 mL water swallows were recorded with a solid-state manometric assembly incorporating 36 circumferential sensors spaced at 1-cm intervals. RESULTS: The resting lower esophageal sphincter pressure was greater in achalasia than in controls or gastroesophageal reflux disease. There was an absence of peristalsis in the smooth muscle esophagus and failure of lower esophageal sphincter relaxation. The resting upper esophageal sphincter pressure was not different among the 3 groups. In addition to the typical manometric findings of achalasia, new observations are included. Esophageal shortening, pressurization of the esophagus, and rhythmic contractions of the upper esophageal sphincter and striated muscle esophagus were frequently observed. CONCLUSIONS: HRM demonstrates alterations of esophageal motor function in achalasia that are not easily observed with other manometric techniques. |
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Authors:
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Sam-Ryong Jee; Mark Pimentel; Edy Soffer; Jeffrey L Conklin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical gastroenterology Volume: 43 ISSN: 1539-2031 ISO Abbreviation: J. Clin. Gastroenterol. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-07-20 Completed Date: 2009-10-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7910017 Medline TA: J Clin Gastroenterol Country: United States |
Other Details:
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Languages: eng Pagination: 644-51 Citation Subset: IM |
Affiliation:
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GI Motility Program, Division of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Case-Control Studies Esophageal Achalasia / diagnosis*, physiopathology Esophageal Sphincter, Lower / physiopathology Esophageal Sphincter, Upper / physiopathology Female Gastroesophageal Reflux / diagnosis*, physiopathology Humans Male Manometry / methods* Middle Aged Peristalsis Retrospective Studies Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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