Document Detail


High resolution SE-fMRI in humans at 3 and 7 T using a motor task.
MedLine Citation:
PMID:  18087739     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECT: The sensitivity of spin echo (SE) experiments to blood oxygenation level dependent (BOLD) contrast was explored in a study of the same six subjects carried out at 3 and 7 T.
MATERIALS AND METHODS: Multi-slice, single shot, spin echo, echo planar images with a voxel size of 1 x 1 x 3 mm3 were acquired at three different echo times, during execution of a simple motor task.
RESULTS: Significant activation was observed at all echo times at both field strengths. Analysis of the fractional signal change as a function of echo time indicated that the change in relaxation rate, Delta R2, at 7 T was -0.51 +/- 0.14 s (-1), which was 1.3 times larger than the value found at 3 T. Measurements of the percentage signal change on activation and temporal signal to noise ratio showed that there was an increase in the BOLD contrast to noise ratio (CNR) at 7 versus 3 T by a factor of 1.9. There was no overlap of areas of significant activation in the SE data acquired at either field strength with the site of large veins.
CONCLUSION: SE-BOLD CNR in motor cortex was found to increase significantly at 7 T compared with 3 T.
Authors:
Andreas Schäfer; Wietske van der Zwaag; Susan T Francis; Kay E Head; Penny A Gowland; Richard W Bowtell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-12-18
Journal Detail:
Title:  Magma (New York, N.Y.)     Volume:  21     ISSN:  0968-5243     ISO Abbreviation:  MAGMA     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-04-08     Completed Date:  2008-08-11     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  9310752     Medline TA:  MAGMA     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  113-20     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Brain Mapping / methods
Female
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging / methods*
Magnetics
Male
Models, Statistical
Motor Cortex / pathology*
Motor Skills*
Oxygen / blood
Pattern Recognition, Visual
Sensitivity and Specificity
Time Factors
Grant Support
ID/Acronym/Agency:
G9900259//Medical Research Council; //Medical Research Council
Chemical
Reg. No./Substance:
S88TT14065/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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