| High-resolution MRI characterization of human thrombus using a novel fibrin-targeted paramagnetic nanoparticle contrast agent. | |
| | |
MedLine Citation:
|
PMID: 11108623 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In this study, the sensitivity of a novel fibrin-targeted contrast agent for fibrin detection was defined in vitro on human thrombus. The contrast agent was a lipid-encapsulated perfluorocarbon nanoparticle with numerous Gd-DTPA complexes incorporated into the outer surface. After binding to fibrin clots, scanning electron microscopy of treated clots revealed dense accumulation of nanoparticles on the clot surfaces. Fibrin clots with sizes ranging from 0.5-7.0 mm were imaged at 4.7 T with or without treatment with the targeted contrast agent. Regardless of sizes, untreated clots were not detectable by T(1)-weighted MRI, while targeted contrast agent dramatically improved the detectability of all clots. Decreases in T(1) and T(2) relaxation times (20-40%) were measured relative to the surrounding media and the control clots. These results suggest the potential for sensitive and specific detection of microthrombi that form on the intimal surfaces of unstable atherosclerotic plaque. |
| | |
Authors:
|
X Yu; S K Song; J Chen; M J Scott; R J Fuhrhop; C S Hall; P J Gaffney; S A Wickline; G M Lanza |
Related Documents
:
|
19795893 - Detecting vascular biosignatures with a colloidal, radio-opaque polymeric nanoparticle. 15503653 - Gadofosveset (epix/schering). 22696003 - Interventional radiology at the meetings of the german radiological society from 1998 t... |
Publication Detail:
|
Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 44 ISSN: 0740-3194 ISO Abbreviation: Magn Reson Med Publication Date: 2000 Dec |
Date Detail:
|
Created Date: 2001-01-09 Completed Date: 2001-01-09 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 867-72 Citation Subset: IM |
Affiliation:
|
Department of Medicine, Cardiovascular Division, Barnes-Jewish Hospital, Washington University School of Medicine, St. Louis, Missouri, USA. xin@cvu.wustl.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antibodies, Monoclonal
/
diagnostic use Biotinylation Contrast Media* Drug Evaluation, Preclinical Fibrin / diagnostic use*, immunology, ultrastructure Gadolinium DTPA / diagnostic use* Humans Hydrocarbons, Chlorinated / diagnostic use* Hydrocarbons, Fluorinated / diagnostic use* Magnetic Resonance Imaging / methods* Microscopy, Electron, Scanning Particle Size Plasma Sensitivity and Specificity Thrombosis / blood, diagnosis* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
|
R01 HL-59865/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Antibodies, Monoclonal; 0/Contrast Media; 0/Hydrocarbons, Chlorinated; 0/Hydrocarbons, Fluorinated; 0/perfluorodichlorooctane; 80529-93-7/Gadolinium DTPA; 9001-31-4/Fibrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Different magnetization transfer effects exhibited by the short and long T(2) components in human br...
Next Document: Magnetic resonance thermometry for predicting thermal damage: an application of interstitial laser c...