| High resolution Fourier-domain optical coherence tomography of retinal angiomatous proliferation. | |
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MedLine Citation:
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PMID: 17891017 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To study the anatomic details of retinal angiomatous proliferation (RAP) in patients with age-related macular degeneration (AMD) using high-resolution Fourier-domain optical coherence tomography (Fd-OCT) and its three-dimensional reconstructions. METHODS: A Fd-OCT instrument was used to image five patients clinically diagnosed with RAP. A series of 100 raster-scanned B-scans centered over the macula was registered and rendered as a three-dimensional volume. These retinal structures were analyzed for anatomic details of the RAP lesions. RESULTS: The RAP lesion could be identified within the retina on Fd-OCT in all five cases. Fd-OCT images of the first four cases revealed areas of intraretinal neovascularization (IRN) in the deep retina adjacent to a pigment epithelial detachment (PED). There was neovascular proliferation anteriorly and posteriorly through a break in the retinal pigment epithelium (RPE). In three of the four cases, Bruch membrane remained intact. There was no identifiable choroidal neovascularization (CNV). The fifth case had both subretinal and sub-RPE neovascular membranes without a PED. CONCLUSION: Fd-OCT provides unprecedented in vivo detail of the anatomy of RAP lesions that nearly resembles histologic specimens. This study suggests that the initial neovascular process in RAP can originate either within the retina or in the sub-RPE space. |
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Authors:
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Steven N Truong; Suhail Alam; Robert J Zawadzki; Stacey S Choi; David G Telander; Susanna S Park; John S Werner; Lawrence S Morse |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Retina (Philadelphia, Pa.) Volume: 27 ISSN: 0275-004X ISO Abbreviation: Retina (Philadelphia, Pa.) Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-09-24 Completed Date: 2007-11-19 Revised Date: 2011-05-16 |
Medline Journal Info:
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Nlm Unique ID: 8309919 Medline TA: Retina Country: United States |
Other Details:
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Languages: eng Pagination: 915-25 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology and Vision Science, University of California, Davis Medical Center, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Female Fluorescein Angiography Fourier Analysis* Humans Image Processing, Computer-Assisted Imaging, Three-Dimensional Macular Degeneration / complications Male Middle Aged Pigment Epithelium of Eye / pathology Retina / pathology Retinal Neovascularization / diagnosis*, etiology Tomography, Optical Coherence / methods* |
| Grant Support | |
ID/Acronym/Agency:
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014743//PHS HHS; R01 EY014743-05/EY/NEI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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