Document Detail

High-resolution FISH mapping of beta-defensin genes to river buffalo and sheep chromosomes suggests a chromosome discrepancy in ffttle standard karyotypes.
MedLine Citation:
PMID:  8995479     Owner:  NLM     Status:  MEDLINE    
High-resolution chromosomal fluorescence in situ hybridization (FISH) and R-banding allowed the chromosomal localization of the beta-defensin gene cluster (DEFB@) to chromosome band 1p12 in the river buffalo (Bubalus bubalis, 2n = 50) and to band 24q13 in sheep (Ovis aries, 2n = 54), according to standard nomenclatures. The localizations permitted the tentative assignment of the entire bovine syntenic group U25 to these chromosomes. A FISH mapping control on cattle chromosomes confirmed the localization of DEFB@ in the homoeologous chromosome and chromosome band. Comparisons were made between river buffalo chromosome 1p and the homoeologous cattle chromosome on standard karyotypes; the results are discussed in light of gene assignments, extensive chromosome band conservation among the Bovidae, and inconsistencies in domestic cattle chromosome nomenclatures.
L Iannuzzi; D S Gallagher; G P Di Meo; G Diamond; C L Bevins; J E Womack
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Cytogenetics and cell genetics     Volume:  75     ISSN:  0301-0171     ISO Abbreviation:  Cytogenet. Cell Genet.     Publication Date:  1996  
Date Detail:
Created Date:  1997-01-30     Completed Date:  1997-01-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0367735     Medline TA:  Cytogenet Cell Genet     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  10-3     Citation Subset:  IM    
National Research Council (CNR), IABBAM, Naples, Italy.
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MeSH Terms
Blood Proteins / genetics*
Buffaloes / genetics*
Cattle / genetics*
Chromosome Banding
Chromosome Mapping*
Genetic Markers
In Situ Hybridization, Fluorescence
Multigene Family*
Sheep / genetics*
Terminology as Topic
Reg. No./Substance:
0/Blood Proteins; 0/Defensins; 0/Genetic Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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