Document Detail

High-resolution 3D proton spectroscopic imaging of the human brain at 3 T: SNR issues and application for anatomy-matched voxel sizes.
MedLine Citation:
PMID:  12541250     Owner:  NLM     Status:  MEDLINE    
In a systematic study on the interdependence of linewidth, signal-to-noise ratio (SNR), and spatial resolution in 3D proton spectroscopic imaging ((1)H-SI) at 3 T, we demonstrate reduced linewidths with increased spatial resolution due to reduced magnetic inhomogeneity within the brain. High-precision quantitative data (0.75-0.094 cm(3)) were obtained for all resolutions, enabling the creation of metabolic maps that display details such as the ventricles, sulci, and gyri. High-resolution (1)H-SI allows differences in metabolic ratios to be estimated for anatomically defined regions in gray (GM) and white matter (WM). Seven distinct regions in a healthy brain were anatomically segmented and their metabolic ratios were compared quantitatively. Data from a tumor patient are also presented to demonstrate potential clinical applications. Because of the high resolution, the metabolite ratios could be determined for distinct pathologic regions within the tumor and its surroundings. The method was additionally applied to a patient with patchy Pelizaeus Merzbacher disease (PMD), and compared to single-voxel spectroscopy performed in the same session. High-resolution SI data were demonstrated in our study to allow the direct matching of anatomic and metabolic images. This may enhance the clinical value of (1)H-SI.
Stephan Gruber; Vladimir Mlynárik; Ewald Moser
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  49     ISSN:  0740-3194     ISO Abbreviation:  Magn Reson Med     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-01-23     Completed Date:  2003-05-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  299-306     Citation Subset:  IM    
Copyright Information:
Copyright 2003 Wiley-Liss, Inc.
NMR Group, Institute of Medical Physics, University of Vienna, Vienna, Austria.
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MeSH Terms
Aspartic Acid / analogs & derivatives*
Brain / anatomy & histology*,  metabolism*
Brain Neoplasms / metabolism,  pathology
Imaging, Three-Dimensional*
Magnetic Resonance Spectroscopy*
Pelizaeus-Merzbacher Disease / metabolism,  pathology
Reg. No./Substance:
56-84-8/Aspartic Acid; 57-00-1/Creatine; 62-49-7/Choline; 997-55-7/N-acetylaspartate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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