| High resolution 3D perspective of Plasmodium biology: advancing into a new era. | |
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MedLine Citation:
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PMID: 21893431 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Apicomplexan parasites exhibit a great variety of complex life cycles that require adaptation to different niches of parasitism. They invade different host cells and highjack their biological functions. Plasmodium falciparum, responsible for the deadliest form of human malaria, causes disease while completely remodeling the erythrocytes of its human host through mechanisms that are only partly understood. Recent developments in ultrastructural technologies offer new opportunities to investigate fundamental aspects in the biology of the parasite in a three-dimensional (3D) perspective. Here we bring together recent work on host cell invasion, hemoglobin uptake, protein export and nuclear dynamics. A comprehensive 3D view of the ultrastructural biology of the parasite may shed new light on cellular mechanisms that underlie the pathogenicity of P. falciparum. |
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Authors:
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Shiri Eshar; Noa Dahan-Pasternak; Allon Weiner; Ron Dzikowski |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-3 |
Journal Detail:
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Title: Trends in parasitology Volume: - ISSN: 1471-5007 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100966034 Medline TA: Trends Parasitol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Microbiology and Molecular Genetics, The Kuvin Center for the Study of Infectious and Tropical Diseases, IMRIC, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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