| High relatedness maintains multicellular cooperation in a social amoeba by controlling cheater mutants. | |
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MedLine Citation:
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PMID: 17496139 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The control of cheating is important for understanding major transitions in evolution, from the simplest genes to the most complex societies. Cooperative systems can be ruined if cheaters that lower group productivity are able to spread. Kin-selection theory predicts that high genetic relatedness can limit cheating, because separation of cheaters and cooperators limits opportunities to cheat and promotes selection against low-fitness groups of cheaters. Here, we confirm this prediction for the social amoeba Dictyostelium discoideum; relatedness in natural wild groups is so high that socially destructive cheaters should not spread. We illustrate in the laboratory how high relatedness can control a mutant that would destroy cooperation at low relatedness. Finally, we demonstrate that, as predicted, mutant cheaters do not normally harm cooperation in a natural population. Our findings show how altruism is preserved from the disruptive effects of such mutant cheaters and how exceptionally high relatedness among cells is important in promoting the cooperation that underlies multicellular development. |
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Authors:
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Owen M Gilbert; Kevin R Foster; Natasha J Mehdiabadi; Joan E Strassmann; David C Queller |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2007-05-11 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 104 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-05-23 Completed Date: 2007-08-01 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 8913-7 Citation Subset: IM |
Affiliation:
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Department of Ecology and Evolutionary Biology, Rice University, MS 170, 6100 Main Street, Houston, TX 77005, USA. og@rice.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dictyostelium / genetics* Evolution, Molecular F-Box Proteins / genetics, metabolism Mutant Chimeric Proteins / genetics Mutation / genetics Protozoan Proteins / genetics, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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5T15 LM07093/LM/NLM NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/F-Box Proteins; 0/FbxA protein, Dictyostelium; 0/Mutant Chimeric Proteins; 0/Protozoan Proteins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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