| High rate of Exophiala dermatitidis recovery in the airways of patients with cystic fibrosis is associated with pancreatic insufficiency. | |
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MedLine Citation:
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PMID: 21209163 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The black-pigmented fungus Exophiala dermatitidis is considered to be a harmless colonizer of the airways of cystic fibrosis (CF) patients. The aim of this study was to establish the recovery rate of E. dermatitidis in respiratory specimens from CF patients, transplant recipients, and subjects with other respiratory disorders in Sweden. Second, we wished to determine if particular clinical traits were associated with E. dermatitidis colonization of the airways and the antifungal susceptibility profiles of Exophiala strains. Sputum and bronchoalveolar lavage samples (n = 492) derived from 275 patients were investigated. E. dermatitidis was isolated in respiratory specimens from 19% (18/97) of the CF patients but in none of the other patient categories. All isolates were recovered after 6 to 25 days of incubation on erythritol-chloramphenicol agar (ECA) medium. Morphological and genetic analyses confirmed species identity. Pancreatic insufficiency was positively associated with the presence of E. dermatitidis in sputum samples (P = 0.0198). Antifungal susceptibility tests demonstrated that voriconazole and posaconazole had the lowest MICs against E. dermatitidis. In conclusion, E. dermatitidis is a frequent colonizer of the respiratory tract in CF patients in Sweden and appears to be associated with more advanced disease. Whether E. dermatitidis is pathogenic remains to be elucidated. |
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Authors:
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Nahid Kondori; Marita Gilljam; Anders Lindblad; Bodil Jönsson; Edward R B Moore; Christine Wennerås |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-01-05 |
Journal Detail:
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Title: Journal of clinical microbiology Volume: 49 ISSN: 1098-660X ISO Abbreviation: J. Clin. Microbiol. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-04 Completed Date: 2011-05-31 Revised Date: 2011-09-13 |
Medline Journal Info:
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Nlm Unique ID: 7505564 Medline TA: J Clin Microbiol Country: United States |
Other Details:
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Languages: eng Pagination: 1004-9 Citation Subset: IM |
Affiliation:
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Department of Clinical Bacteriology, Sahlgrenska University Hospital, 40234 Gothenburg, Sweden. nahid.kondori@microbio.gu.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Antifungal Agents / pharmacology Bronchoalveolar Lavage Fluid / microbiology Carrier State / microbiology* Cystic Fibrosis / complications* Exocrine Pancreatic Insufficiency / complications* Exophiala / classification, drug effects, genetics, isolation & purification* Female Humans Male Microbial Sensitivity Tests Middle Aged Mycoses / microbiology Prevalence Respiratory Tract Infections / microbiology* Sputum / microbiology Sweden Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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