|High ratio of myeloid dendritic cells to plasmacytoid dendritic cells in blood of patients with acute coronary syndrome.|
|PMID: 19644219 Owner: NLM Status: MEDLINE|
|BACKGROUND: Dendritic cells (DCs) stimulate T-cells to participate in the inflammatory processes that promote the destruction of vulnerable plaques. The relationship between circulating levels of myeloid DCs (mDCs) and plasmacytoid DCs (pDCs) in patients with acute coronary syndrome (ACS) was evaluated. METHODS AND RESULTS: Blood samples were obtained from 39 patients with ACS, 41 patients with stable angina pectoris (SAP) and 43 controls. The proportion of mDCs tended to be lower in the ACS group than in the SAP group and controls. Interleukin-12 levels associated with mDCs were significantly higher in the ACS group than in control group. The proportion of pDCs was significantly lower in the ACS groups than in the other two groups. Interferon-alpha levels secreted by pDCs, however, were not significantly different among the 3 groups. The ratio of mDCs to pDCs >or=4 is an important value for distinguishing ACS from SAP patients and control patients through receiver operating characteristic analysis (sensitivity; 85.0%, specificity; 83.4%). CONCLUSIONS: The ratio of mDCs to pDCs may be a useful marker for detecting ACS and the existence of vulnerable plaques.|
|Takashi Fukunaga; Hirofumi Soejima; Atsushi Irie; Ryuichiro Fukushima; Yoko Oe; Hiroaki Kawano; Hitoshi Sumida; Koichi Kaikita; Seigo Sugiyama; Yasuharu Nishimura; Hisao Ogawa|
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|Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-07-31|
|Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 73 ISSN: 1347-4820 ISO Abbreviation: Circ. J. Publication Date: 2009 Oct|
|Created Date: 2009-09-25 Completed Date: 2009-12-07 Revised Date: -|
Medline Journal Info:
|Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan|
|Languages: eng Pagination: 1914-9 Citation Subset: IM|
|Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.|
|APA/MLA Format Download EndNote Download BibTex|
Acute Coronary Syndrome
Aged, 80 and over
Angina Pectoris / diagnosis, immunology*
Biological Markers / blood
C-Reactive Protein / metabolism
Coronary Artery Disease / diagnosis, immunology*
Dendritic Cells / immunology*
Inflammation Mediators / blood
Interferon-alpha / blood
Interleukin-12 / blood
Myeloid Cells / immunology*
Predictive Value of Tests
|0/Biological Markers; 0/Inflammation Mediators; 0/Interferon-alpha; 187348-17-0/Interleukin-12; 9007-41-4/C-Reactive Protein|
|Circ J. 2009 Oct;73(10):1799-800
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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