Document Detail


High ratio of myeloid dendritic cells to plasmacytoid dendritic cells in blood of patients with acute coronary syndrome.
MedLine Citation:
PMID:  19644219     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Dendritic cells (DCs) stimulate T-cells to participate in the inflammatory processes that promote the destruction of vulnerable plaques. The relationship between circulating levels of myeloid DCs (mDCs) and plasmacytoid DCs (pDCs) in patients with acute coronary syndrome (ACS) was evaluated. METHODS AND RESULTS: Blood samples were obtained from 39 patients with ACS, 41 patients with stable angina pectoris (SAP) and 43 controls. The proportion of mDCs tended to be lower in the ACS group than in the SAP group and controls. Interleukin-12 levels associated with mDCs were significantly higher in the ACS group than in control group. The proportion of pDCs was significantly lower in the ACS groups than in the other two groups. Interferon-alpha levels secreted by pDCs, however, were not significantly different among the 3 groups. The ratio of mDCs to pDCs >or=4 is an important value for distinguishing ACS from SAP patients and control patients through receiver operating characteristic analysis (sensitivity; 85.0%, specificity; 83.4%). CONCLUSIONS: The ratio of mDCs to pDCs may be a useful marker for detecting ACS and the existence of vulnerable plaques.
Authors:
Takashi Fukunaga; Hirofumi Soejima; Atsushi Irie; Ryuichiro Fukushima; Yoko Oe; Hiroaki Kawano; Hitoshi Sumida; Koichi Kaikita; Seigo Sugiyama; Yasuharu Nishimura; Hisao Ogawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-07-31
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  73     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-25     Completed Date:  2009-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1914-9     Citation Subset:  IM    
Affiliation:
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
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MeSH Terms
Descriptor/Qualifier:
Acute Coronary Syndrome / diagnosis,  immunology*
Aged
Aged, 80 and over
Angina Pectoris / diagnosis,  immunology*
Biological Markers / blood
C-Reactive Protein / metabolism
Case-Control Studies
Cell Count
Cell Separation
Coronary Artery Disease / diagnosis,  immunology*
Dendritic Cells / immunology*
Diagnosis, Differential
Female
Flow Cytometry
Humans
Inflammation Mediators / blood
Interferon-alpha / blood
Interleukin-12 / blood
Logistic Models
Male
Middle Aged
Myeloid Cells / immunology*
Odds Ratio
Predictive Value of Tests
ROC Curve
Risk Assessment
Rupture
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Inflammation Mediators; 0/Interferon-alpha; 187348-17-0/Interleukin-12; 9007-41-4/C-Reactive Protein
Comments/Corrections
Comment In:
Circ J. 2009 Oct;73(10):1799-800   [PMID:  19779274 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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