Document Detail


High rate of maternal vitamin B12 deficiency nearly a decade after Canadian folic acid flour fortification.
MedLine Citation:
PMID:  18337285     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vitamin B12 deficiency may be an independent risk factor for neural tube defects (NTD). We determined the prevalence of biochemical B12 deficiency (<125 pmol/l) among 10 622 Ontarian women aged 15-46 years who underwent concomitant testing of serum bhCG and B12 9 years after the implementation of Canadian folic acid flour fortification. The overall prevalence of biochemical B12 deficiency was 7.4%. Relative to non-pregnant women, the adjusted odds ratio (95% confidence interval) of biochemical B12 deficiency was 0.78 (0.60-1.0) among women pregnant 28 days gestation or less and was 1.4 (1.1-1.8) after 28 days gestation. About 1 in 20 women may be deficient in B12 in early pregnancy. The impact on maternal and fetal well-being, including preventable NTD, should be considered.
Authors:
J G Ray; J Goodman; P R A O'Mahoney; M M Mamdani; D Jiang
Related Documents :
5354835 - Severe haemolytic anaemia in pregnancy in nigerians treated with prednisolone.
453065 - Dietary zinc intake of low-income pregnant women of mexican descent.
2920535 - Maternal zinc during oral iron supplementation in pregnancy: a preliminary study.
20974415 - Specialized care for women pregnant after bariatric surgery.
15526515 - Relapsing polychondritis with splenic abscess.
7698135 - Pregnancy and prosthetic heart valves: a french cooperative retrospective study of 155 ...
Publication Detail:
Type:  Journal Article     Date:  2008-03-12
Journal Detail:
Title:  QJM : monthly journal of the Association of Physicians     Volume:  101     ISSN:  1460-2393     ISO Abbreviation:  QJM     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-23     Completed Date:  2008-08-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9438285     Medline TA:  QJM     Country:  England    
Other Details:
Languages:  eng     Pagination:  475-7     Citation Subset:  IM    
Affiliation:
Department of Medicine, St Michael's Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, Canada. rayj@smh.toronto.on.ca
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Canada / epidemiology
Cross-Sectional Studies
Female
Folic Acid / administration & dosage*,  blood
Folic Acid Deficiency / blood,  epidemiology*
Follow-Up Studies
Food, Fortified*
Humans
Infant, Newborn
Middle Aged
Neural Tube Defects / epidemiology*,  prevention & control,  ultrasonography
Pregnancy
Pregnancy Complications / blood,  epidemiology*
Pregnancy Outcome
Risk Assessment
Ultrasonography, Prenatal
Vitamin B 12 Deficiency / blood,  epidemiology*
Chemical
Reg. No./Substance:
59-30-3/Folic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Once-daily amoxicillin versus twice-daily penicillin V in group A beta-haemolytic streptococcal phar...
Next Document:  Attitudes toward the large-scale implementation of an incident reporting system.