Document Detail

High rate of maternal vitamin B12 deficiency nearly a decade after Canadian folic acid flour fortification.
MedLine Citation:
PMID:  18337285     Owner:  NLM     Status:  MEDLINE    
Vitamin B12 deficiency may be an independent risk factor for neural tube defects (NTD). We determined the prevalence of biochemical B12 deficiency (<125 pmol/l) among 10 622 Ontarian women aged 15-46 years who underwent concomitant testing of serum bhCG and B12 9 years after the implementation of Canadian folic acid flour fortification. The overall prevalence of biochemical B12 deficiency was 7.4%. Relative to non-pregnant women, the adjusted odds ratio (95% confidence interval) of biochemical B12 deficiency was 0.78 (0.60-1.0) among women pregnant 28 days gestation or less and was 1.4 (1.1-1.8) after 28 days gestation. About 1 in 20 women may be deficient in B12 in early pregnancy. The impact on maternal and fetal well-being, including preventable NTD, should be considered.
J G Ray; J Goodman; P R A O'Mahoney; M M Mamdani; D Jiang
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Publication Detail:
Type:  Journal Article     Date:  2008-03-12
Journal Detail:
Title:  QJM : monthly journal of the Association of Physicians     Volume:  101     ISSN:  1460-2393     ISO Abbreviation:  QJM     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-23     Completed Date:  2008-08-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9438285     Medline TA:  QJM     Country:  England    
Other Details:
Languages:  eng     Pagination:  475-7     Citation Subset:  IM    
Department of Medicine, St Michael's Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, Canada.
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MeSH Terms
Canada / epidemiology
Cross-Sectional Studies
Folic Acid / administration & dosage*,  blood
Folic Acid Deficiency / blood,  epidemiology*
Follow-Up Studies
Food, Fortified*
Infant, Newborn
Middle Aged
Neural Tube Defects / epidemiology*,  prevention & control,  ultrasonography
Pregnancy Complications / blood,  epidemiology*
Pregnancy Outcome
Risk Assessment
Ultrasonography, Prenatal
Vitamin B 12 Deficiency / blood,  epidemiology*
Reg. No./Substance:
59-30-3/Folic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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