Document Detail


High rate of hepatitis C virus clearance in hemodialysis patients after interferon-alpha therapy.
MedLine Citation:
PMID:  9395376     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To gain insight into the long-term effect of interferon-alpha (IFN-alpha) therapy on hepatitis C virus (HCV) RNA-positive hemodialysis patients, 23 subjects were given 3 MU of IFN-alpha 3 times a week for 6 (n = 12) or 12 months (n = 11). They were followed for 19 months after cessation of therapy. Sustained serum HCV RNA clearance occurred in 42% of patients treated for 6 months and in 64% of those treated for 12 months. HCV was eradicated from 6 of 13 patients infected with HCV genotype 1b and from 2 of 6 patients also infected with hepatitis G virus. HCV RNA remained undetectable in both serum and a liver biopsy of 2 patients who were given cadaveric kidney transplants after IFN-alpha treatment. These data suggest that HCV RNA-positive dialysis patients can be considered for treatment while receiving dialysis, particularly those awaiting transplant.
Authors:
J Izopet; L Rostaing; F Moussion; L Alric; M Dubois; H T That; J L Payen; M Duffaut; D Durand; J M Suc; J Puel
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Multicenter Study    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  176     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-01-15     Completed Date:  1998-01-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1614-7     Citation Subset:  AIM; IM    
Affiliation:
Laboratoire de Virologie, and Service de Médecine Interne, Hôpital Purpan, Centre Hospitalier Toulouse, France.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antiviral Agents / administration & dosage,  therapeutic use*
Female
Flaviviridae / genetics,  isolation & purification
Hepacivirus / genetics,  isolation & purification*
Hepatitis C Antibodies / analysis
Hepatitis C, Chronic / drug therapy*,  virology
Hepatitis, Viral, Human / complications,  diagnosis
Humans
Interferon Alfa-2b / administration & dosage,  therapeutic use*
Kidney Transplantation / adverse effects
Liver / virology
Male
Middle Aged
Pilot Projects
RNA, Viral / analysis,  blood
Renal Dialysis*
Transaminases / metabolism
Chemical
Reg. No./Substance:
0/Antiviral Agents; 0/Hepatitis C Antibodies; 0/RNA, Viral; 99210-65-8/Interferon Alfa-2b; EC 2.6.1.-/Transaminases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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