| High rate of deficiency in the amino acids tryptophan and histidine in people with wounds: implication for nutrient targeting in wound management--a pilot study. | |
| | |
MedLine Citation:
|
PMID: 19155712 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Malnutrition resulting from inadequate protein, energy, or micronutrient intake has been identified as an independent risk factor for the development of pressure ulcers in older adult patients and is associated with increased morbidity and death. OBJECTIVE: To assess the relationship between albumin, the standard biochemical marker of nutritional adequacy, and amino acid status in people with wounds. METHODS: The authors performed tests for serum albumin, prealbumin, and amino acid profiles on 18 consecutive hospital patients with wounds and 7 patients without wounds. RESULTS: A low level of the essential amino acids tryptophan and histidine was a common finding in older people with wounds. Of the 18 consecutive wound cases, 16 (88.9%) were found to be deficient in tryptophan, histidine, or both. Moreover, levels were generally found to be lower than those in the group without wounds. The levels of all other amino acids were essentially normal for all patients. Finally, although serum albumin is often used as a surrogate marker of amino acid adequacy or nutritional status, clinically abnormal albumin had poor specificity (63.2%), poor sensitivity (60.7%), and low positive predictive value (70.8%) for the identification of a low tryptophan or histidine level. CONCLUSIONS: People with wounds are a relatively at-risk group and are likely to be overlooked in terms of micronutrient deficiencies, and these findings have important implications in terms of potential specific targeting of nutrient supplementation. |
| | |
Authors:
|
Beryl Dawson; Emmanuel J Favaloro |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Advances in skin & wound care Volume: 22 ISSN: 1538-8654 ISO Abbreviation: Adv Skin Wound Care Publication Date: 2009 Feb |
Date Detail:
|
Created Date: 2009-01-21 Completed Date: 2009-05-13 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100911021 Medline TA: Adv Skin Wound Care Country: United States |
Other Details:
|
Languages: eng Pagination: 79-82 Citation Subset: N |
Affiliation:
|
Department of Nutrition and Dietetics, Balmain Hospital, Balmain NSW, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Albumins* Antidepressive Agents, Second-Generation* Biological Markers Case-Control Studies Dietary Supplements Female Histidine / deficiency* Humans Male Middle Aged Nutritional Status* Pilot Projects Risk Assessment Tryptophan / deficiency* Wound Healing* Wounds and Injuries / diet therapy* |
| Chemical | |
Reg. No./Substance:
|
0/Albumins; 0/Antidepressive Agents, Second-Generation; 0/Biological Markers; 71-00-1/Histidine; 73-22-3/Tryptophan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The role of interventional patient hygiene in improving clinical and economic outcomes.
Next Document: The nursing process and pressure ulcer prevention: making the connection.