Document Detail


High rate of biological loss in assisted reproduction: it is in the seed, not in the soil.
MedLine Citation:
PMID:  17207339     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The vast majority of embryos produced in vitro and transferred fail to develop into an infant, supporting the concept that only a small fraction of embryos is destined to become a live birth. One of the main reasons for such a low embryo-to-infant ratio is the remarkably high number of embryos that after preimplantation genetic diagnosis are found to have a chromosome imbalance. This study reports the overall biological wastage from oocytes inseminated to ongoing pregnancies in patients undergoing preimplantation genetic screening (PGS) because of advanced age, recurrent pregnancy losses or multiple failed IVF cycles. The analysis of biological wastage per oocyte showed that in this cohort of patients, of 333 eggs inseminated, 183 (55.0%) provided embryos for biopsy, and of these, only 33 (18.0% per embryo and 9.9% per oocyte) were normal. A total of 26 embryos were suitable for transfer (14% per embryo and 7.8% per oocyte), but only five (1.5%) implanted and three (1.0%) resulted in live births. In conclusion, there is enormous biological wastage during assisted reproduction, and the data obtained from both embryos and oocytes of patients undergoing PGS support the concept that many embryos and eggs obtained during IVF are intrinsically abnormal and thus fail to implant.
Authors:
P Patrizio; V Bianchi; M D Lalioti; T Gerasimova; D Sakkas
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Reproductive biomedicine online     Volume:  14     ISSN:  1472-6483     ISO Abbreviation:  Reprod. Biomed. Online     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-08     Completed Date:  2007-02-28     Revised Date:  2010-05-27    
Medline Journal Info:
Nlm Unique ID:  101122473     Medline TA:  Reprod Biomed Online     Country:  England    
Other Details:
Languages:  eng     Pagination:  92-5     Citation Subset:  IM    
Affiliation:
Yale University Fertility Centre, 150 Sargent Drive, New Haven, CT 06511, USA. pasquale.patrizio@yale.edu
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MeSH Terms
Descriptor/Qualifier:
Chromosome Aberrations
Cohort Studies
Embryo Implantation
Embryo Loss* / genetics
Embryo Transfer
Embryo, Mammalian / physiology
Female
Fertilization in Vitro* / standards
Genetic Testing*
Humans
Infertility / therapy
Male
Maternal Age
Treatment Failure
Comments/Corrections
Republished in:
Reprod Biomed Online. 2007;14 Spec No 1:23-6   [PMID:  20483396 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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