Document Detail


High rate of O2 consumption in exercising foxes: large PO2 difference drives diffusion across the lung.
MedLine Citation:
PMID:  2781165     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The fox has one of the highest mass specific rates of maximal oxygen consumption (VO2max/Mb) that has been measured, yet its specific pulmonary diffusing capacity (DLO2/Mb, measured morphometrically) is similar to that of most mammalian species. It achieves a high O2 flux per unit DLO2 with a large partial pressure difference driving O2 diffusion from alveolar gas to capillary blood (PAO2-PbO2). This paper explores the mechanisms that the fox utilizes to achieve this large pressure difference and the extent to which it exploits its structural diffusing capacity. Foxes were exercised on a treadmill at maximal rates of O2 uptake. The following parameters were measured or calculated: arterial and mixed venous PO2, PCO2, pH and O2 concentration of the blood, cardiac output, hemoglobin concentration and O2 equilibrium curve of the blood, and morphometric estimates of pulmonary capillary volume and pulmonary diffusing capacity for O2. These data were used to calculate pulmonary capillary transit time and the time course of the change in O2 concentration and PO2 of the blood as it transits the lung. The fox has a morphometric pulmonary diffusing capacity of 0.098 ml O2.sec-1.mm Hg-1.kg-1. At VO2 max (3.6 ml O2.sec-1.kg-1) the fox hyperventilates, resulting in a high PAO2 (124 mm Hg); it also maintains a low PbO2 (88 mm Hg) by having a short transit time (0.13 sec) due to a high specific cardiac output (25 ml.sec-1.kg-1). Our calculations indicate that at VO2max the fox uses almost all of the pulmonary capillary transit time for O2 equilibration, in contrast to other species.
Authors:
K E Longworth; J H Jones; J E Bicudo; C R Taylor; E R Weibel
Related Documents :
3100135 - Nitroglycerin-induced decrease of carbon monoxide diffusion capacity in acute myocardia...
994135 - Pulmonary hypertension in relationship to acidaemia after maximum forced exercise. a fu...
18446125 - A retrospective analysis of terlipressin infusion in patients with refractory hypotensi...
3402465 - Haemodynamic effects of dpi 201-106, following single intravenous dose administration t...
19760725 - Red- and green-emitting iridium(iii) complexes for a dual barometric and temperature-se...
10600855 - Cardiopulmonary baroreceptor control of muscle sympathetic nerve activity in heat-stres...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Respiration physiology     Volume:  77     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1989 Sep 
Date Detail:
Created Date:  1989-10-26     Completed Date:  1989-10-26     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  263-76     Citation Subset:  IM; S    
Affiliation:
Museum of Comparative Zoology, Harvard University, Cambridge, MA 02138.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Foxes / physiology*
Lung / physiology
Oxygen Consumption*
Physical Exertion*
Pulmonary Diffusing Capacity*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Responses of pulmonary slowly adapting receptors to airway occlusion in cat.
Next Document:  Glottic dimensions in healthy men and women.