| High processing tolerances of immunomodulatory proteins in Enoki and Reishi mushrooms. | |
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MedLine Citation:
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PMID: 18422333 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study investigated the processing tolerances of two mushroom proteins with immunomodulatory activities, including FVE from Enoki ( Flammulia velutipes ) and LZ8 from Reishi ( Ganoderma lucidum ) mushrooms, under food processing treatments such as heating, sterilization, frozen storage, extraction in acid/alkaline conditions, and dehydration. Results showed that the capability of these two proteins to induce IFN-gamma secretion by murine splenocytes remained after 100 degrees C heating for 30 min, 121 degrees C autoclaving for 15 min, and -80 degrees C freezing. The retained activities of both proteins on cell proliferation and IFN-gamma production did not decrease at 0.6 M hydrochloric acid (at pH 2) but strikingly dropped at 5 M sodium hydrate (at pH 13). After vacuum dehydration, FVE and LZ8 retained most of their activities on cell proliferation; nevertheless, the IFN-gamma secretion decreased to about half of the initial values. These findings suggest that these two mushroom proteins have a good thermal/freezing resistance, acid tolerance, and dehydration stability and are candidates for processing in food and nutraceutical utilization. |
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Authors:
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Man-Hua Tong; Po-Jung Chien; Hui-Hsin Chang; Ming-Jer Tsai; Fuu Sheu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-04-19 |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: 56 ISSN: 0021-8561 ISO Abbreviation: J. Agric. Food Chem. Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-05-07 Completed Date: 2008-07-21 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: United States |
Other Details:
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Languages: eng Pagination: 3160-6 Citation Subset: IM |
Affiliation:
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Department of Horticulture, National Taiwan University, Taiwan, Republic of China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Agaricales
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chemistry* Animals Cell Division / drug effects Desiccation Drug Stability Female Food Handling / methods* Freezing Fungal Proteins / analysis, pharmacology* Ganoderma / chemistry* Hot Temperature Hydrogen-Ion Concentration Immunity / drug effects* Interferon-gamma / secretion Mice Mice, Inbred BALB C Mice, Inbred C57BL Spleen / cytology, immunology Sterilization |
| Chemical | |
Reg. No./Substance:
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0/Fungal Proteins; 127187-71-7/LZ-8 protein, Ganoderma lucidum; 82115-62-6/Interferon-gamma |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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