Document Detail


High prevalence of vitamin D deficiency in patients with basal cell nevus syndrome.
MedLine Citation:
PMID:  20956641     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To evaluate vitamin D status in patients with basal cell nevus syndrome (BCNS) who practice photoprotection because of their genetic predisposition to skin cancer and to determine risk factors for deficiency.
DESIGN: Retrospective cohort study.
SETTING: Academic medical centers.
PATIENTS: Forty-one ambulatory patients with BCNS who participated in a 2-year chemoprevention clinical trial. Population-based controls (n = 360) were selected and matched by age, sex, Fitzpatrick skin type, and season/geography.
MAIN OUTCOME MEASURES: Levels of 25-hydroxyvitamin D (25[OH]D) and vitamin D deficiency (defined as a 25[OH]D level of ≤20 ng/mL).
RESULTS: Twenty-three patients with BCNS (56%) were vitamin D deficient. Patients with BCNS had mean 25(OH)D levels below those of the general population (-3 ng/mL; P = .02) and were 3 times more likely to be vitamin D deficient (56% vs 18%; P < .001). Levels of 25(OH)D were lower in patients who were overweight (-3.0 ng/mL; P = .04) and who had blood collected in the winter compared with the summer (-7.1 ng/mL; P < .001).
CONCLUSION: Patients with BCNS may be at increased risk for vitamin D deficiency, depending on their adherence to photoprotection practices.
Authors:
Jean Y Tang; Angela Wu; Eleni Linos; Neeta Parimi; Wayne Lee; Michelle Aszterbaum; Maryam M Asgari; David R Bickers; Ervin H Epstein
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of dermatology     Volume:  146     ISSN:  1538-3652     ISO Abbreviation:  Arch Dermatol     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-19     Completed Date:  2010-11-02     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  0372433     Medline TA:  Arch Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1105-10     Citation Subset:  AIM; IM    
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00023621
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MeSH Terms
Descriptor/Qualifier:
Adult
Basal Cell Nevus Syndrome / blood,  complications*
Cohort Studies
Female
Humans
Male
Prevalence
Retrospective Studies
Skin Neoplasms / blood,  complications*
Vitamin D / analogs & derivatives,  blood
Vitamin D Deficiency / blood,  epidemiology*,  etiology*
Grant Support
ID/Acronym/Agency:
1K23AR056736-01/AR/NIAMS NIH HHS; CA81888/CA/NCI NIH HHS; CN-95116/CN/NCI NIH HHS; K23 AR056736/AR/NIAMS NIH HHS; K23 AR056736-03/AR/NIAMS NIH HHS; KL2RR024130/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D
Comments/Corrections

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