| High prevalence of vitamin D deficiency in patients with basal cell nevus syndrome. | |
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MedLine Citation:
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PMID: 20956641 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To evaluate vitamin D status in patients with basal cell nevus syndrome (BCNS) who practice photoprotection because of their genetic predisposition to skin cancer and to determine risk factors for deficiency. DESIGN: Retrospective cohort study. SETTING: Academic medical centers. PATIENTS: Forty-one ambulatory patients with BCNS who participated in a 2-year chemoprevention clinical trial. Population-based controls (n = 360) were selected and matched by age, sex, Fitzpatrick skin type, and season/geography. MAIN OUTCOME MEASURES: Levels of 25-hydroxyvitamin D (25[OH]D) and vitamin D deficiency (defined as a 25[OH]D level of ≤20 ng/mL). RESULTS: Twenty-three patients with BCNS (56%) were vitamin D deficient. Patients with BCNS had mean 25(OH)D levels below those of the general population (-3 ng/mL; P = .02) and were 3 times more likely to be vitamin D deficient (56% vs 18%; P < .001). Levels of 25(OH)D were lower in patients who were overweight (-3.0 ng/mL; P = .04) and who had blood collected in the winter compared with the summer (-7.1 ng/mL; P < .001). Conclusion: Patients with BCNS may be at increased risk for vitamin D deficiency, depending on their adherence to photoprotection practices. |
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Authors:
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Jean Y Tang; Angela Wu; Eleni Linos; Neeta Parimi; Wayne Lee; Michelle Aszterbaum; Maryam M Asgari; David R Bickers; Ervin H Epstein |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of dermatology Volume: 146 ISSN: 1538-3652 ISO Abbreviation: Arch Dermatol Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-19 Completed Date: 2010-11-02 Revised Date: 2012-04-09 |
Medline Journal Info:
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Nlm Unique ID: 0372433 Medline TA: Arch Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 1105-10 Citation Subset: AIM; IM |
Affiliation:
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Department of Dermatology, Stanford University Medical Center, 450 Broadway St, Pavilion C, Redwood City, CA 94063, USA. tangy@stanford.edu |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00023621 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Basal Cell Nevus Syndrome / blood, complications* Cohort Studies Female Humans Male Prevalence Retrospective Studies Skin Neoplasms / blood, complications* Vitamin D / analogs & derivatives, blood Vitamin D Deficiency / blood, epidemiology*, etiology* |
| Grant Support | |
ID/Acronym/Agency:
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1K23AR056736-01/AR/NIAMS NIH HHS; CA81888/CA/NCI NIH HHS; CN-95116/CN/NCI NIH HHS; K23 AR056736-03/AR/NIAMS NIH HHS; K23 AR056736-04/AR/NIAMS NIH HHS; KL2RR024130/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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