Document Detail

High prevalence of vitamin D deficiency in Japanese female patients with Graves' disease.
MedLine Citation:
PMID:  11403104     Owner:  NLM     Status:  MEDLINE    
We reported previously that vitamin D deficiency is a causal mechanism of postoperative tetany in patients with Graves' disease. The aim of the present study was to determine the prevalence of vitamin D deficiency by reviewing serum 25(OH)D levels in 208 patients with Graves' disease (146 women, 62 men) during a 1 year period. Serum 25(OH)D levels were significantly lower (p < 0.001) in female Graves' patients (31.8 +/- 13.3 nmol/l) than in male patients (41.3 +/- 15.0 nmol/l). Vitamin D deficiency (defined as a serum 25(OH)D value below 25 nmol/l) was found in 40% of female patients and in 18% of male patients (p < 0.005). There was a significant seasonal variation in the 25(OH)D concentrations in female patients [amplitude 6.38 (95% CI, 5.42-7.56)], with values below 25 nmol/l found in 58% of female patients during the winter months. There were significant (p < 0.001) differences in serum 25(OH)D levels between age groups in the female patients. The concentrations were lowest in patients in their twenties (25.1 +/- 8.2 nmol/l) and highest in patients in their fifties and sixties (43.2 +/- 13.7 nmol/l). Serum 25(OH)D concentrations might be monitored in patients with Graves' disease during antithyroid drug therapy, and vitamin D and/or calcium supplements are recommended for patients with vitamin D deficiency.
H Yamashita; S Noguchi; K Takatsu; E Koike; T Murakami; S Watanabe; S Uchino; H Yamashita; H Kawamoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Endocrine journal     Volume:  48     ISSN:  0918-8959     ISO Abbreviation:  Endocr. J.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-06-13     Completed Date:  2001-10-25     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9313485     Medline TA:  Endocr J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  63-9     Citation Subset:  IM    
Noguchi Thyroid Clinic and Hospital Foundation, Beppu, Oita, Japan.
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MeSH Terms
Alkaline Phosphatase / blood
Antithyroid Agents / therapeutic use
Calcifediol / blood
Calcium / blood
Graves Disease / blood,  complications*,  drug therapy
Japan / epidemiology
Middle Aged
Sex Characteristics*
Vitamin D Deficiency / complications*,  epidemiology*
Reg. No./Substance:
0/Antithyroid Agents; 19356-17-3/Calcifediol; 7440-70-2/Calcium; EC Phosphatase
Comment In:
Endocr J. 2001 Aug;48(4):515-6   [PMID:  11603577 ]

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