| High prevalence of vitamin D deficiency in Japanese female patients with Graves' disease. | |
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MedLine Citation:
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PMID: 11403104 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We reported previously that vitamin D deficiency is a causal mechanism of postoperative tetany in patients with Graves' disease. The aim of the present study was to determine the prevalence of vitamin D deficiency by reviewing serum 25(OH)D levels in 208 patients with Graves' disease (146 women, 62 men) during a 1 year period. Serum 25(OH)D levels were significantly lower (p < 0.001) in female Graves' patients (31.8 +/- 13.3 nmol/l) than in male patients (41.3 +/- 15.0 nmol/l). Vitamin D deficiency (defined as a serum 25(OH)D value below 25 nmol/l) was found in 40% of female patients and in 18% of male patients (p < 0.005). There was a significant seasonal variation in the 25(OH)D concentrations in female patients [amplitude 6.38 (95% CI, 5.42-7.56)], with values below 25 nmol/l found in 58% of female patients during the winter months. There were significant (p < 0.001) differences in serum 25(OH)D levels between age groups in the female patients. The concentrations were lowest in patients in their twenties (25.1 +/- 8.2 nmol/l) and highest in patients in their fifties and sixties (43.2 +/- 13.7 nmol/l). Serum 25(OH)D concentrations might be monitored in patients with Graves' disease during antithyroid drug therapy, and vitamin D and/or calcium supplements are recommended for patients with vitamin D deficiency. |
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Authors:
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H Yamashita; S Noguchi; K Takatsu; E Koike; T Murakami; S Watanabe; S Uchino; H Yamashita; H Kawamoto |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Endocrine journal Volume: 48 ISSN: 0918-8959 ISO Abbreviation: Endocr. J. Publication Date: 2001 Feb |
Date Detail:
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Created Date: 2001-06-13 Completed Date: 2001-10-25 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9313485 Medline TA: Endocr J Country: Japan |
Other Details:
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Languages: eng Pagination: 63-9 Citation Subset: IM |
Affiliation:
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Noguchi Thyroid Clinic and Hospital Foundation, Beppu, Oita, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Alkaline Phosphatase / blood Antithyroid Agents / therapeutic use Calcifediol / blood Calcium / blood Child Female Graves Disease / blood, complications*, drug therapy Humans Japan / epidemiology Male Middle Aged Seasons Sex Characteristics* Vitamin D Deficiency / complications*, epidemiology* |
| Chemical | |
Reg. No./Substance:
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0/Antithyroid Agents; 19356-17-3/Calcifediol; 7440-70-2/Calcium; EC 3.1.3.1/Alkaline Phosphatase |
| Comments/Corrections | |
Comment In:
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Endocr J. 2001 Aug;48(4):515-6
[PMID:
11603577
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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