| High prevalence of severe nausea and vomiting of pregnancy and hyperemesis gravidarum among relatives of affected individuals. | |
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MedLine Citation:
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PMID: 18752885 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The goal of this study was to determine the prevalence of severe nausea and vomiting of pregnancy/hyperemesis gravidarum among relatives of affected individuals. STUDY DESIGN: Family history data were obtained on 1224 self-reported cases of hyperemesis gravidarum. Cases completed an online survey administered by the Hyperemesis Education and Research Foundation between 2003 and 2006. RESULTS: Approximately 28% of cases reported their mother had severe nausea and vomiting or hyperemesis gravidarum while pregnant with them. Of the 721 sisters with a pregnancy history, 137 (19%) had hyperemesis gravidarum. Among the most severe cases, those requiring total parenteral nutrition or nasogastric feeding tube, the proportion of affected sisters was even higher, 49/198 (25%). Nine percent of cases reported having at least two affected relatives including sister(s), mother, grandmother, daughters, aunt(s), and cousin(s). CONCLUSION: There is a high prevalence of severe nausea and vomiting of pregnancy/hyperemesis gravidarum among relatives of hyperemesis gravidarum cases in this study population. Because the incidence of hyperemesis gravidarum is most commonly reported to be 0.5%, this study provides strong but preliminary evidence for a genetic component to extreme nausea and vomiting of pregnancy. |
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Authors:
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Marlena S Fejzo; Sue Ann Ingles; Melissa Wilson; Wei Wang; Kimber MacGibbon; Roberto Romero; Thomas M Goodwin |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural Date: 2008-08-26 |
Journal Detail:
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Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 141 ISSN: 0301-2115 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-11-05 Completed Date: 2009-03-24 Revised Date: 2010-09-21 |
Medline Journal Info:
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Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: Ireland |
Other Details:
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Languages: eng Pagination: 13-7 Citation Subset: IM |
Affiliation:
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Keck School of Medicine, University of Southern California, Department of Obstetrics and Gynecology, Los Angeles, USA. mfejzo@mednet.ucla.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Cohort Studies Female Genetic Predisposition to Disease* Humans Hyperemesis Gravidarum / genetics* Middle Aged Pedigree Pregnancy Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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N01 HD023342/HD/NICHD NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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