Document Detail

High prevalence of reversible airway obstruction in asbestos-exposed workers.
MedLine Citation:
PMID:  12641187     Owner:  NLM     Status:  MEDLINE    
In this retrospective study of 97 male workers exposed to asbestos for 2-50 yr, data were collected on chest x-ray findings and lung function, including lung volumes, forced expiratory flow rates (i.e., forced expiratory volume in 1 sec [FEV1.0], forced expiratory flow measured between 25% and 75% of forced vital capacity [FEF(25-75%)]), airway resistance (R(aw)), carbon monoxide (CO)-diffusing capacity, and the existence of airway obstruction reversible by a beta-adrenergic agonist (RAO). The authors performed multiple-regression analyses to correlate the variations in lung function data with age, smoking habits, duration of asbestos exposure, and time since last exposure. Occupational activities of subjects that might induce specific lung abnormalities were also considered. No significant decrease was seen in lung volumes or CO-diffusing capacity; however, a decrease in FEV1.0 and an increase in R(aw) were measured in 65% of the subjects, and an isolated decrease in FEF(25-75%) occurred in only 18%. There was no difference in lung-function data between subjects who had chest x-ray signs of abnormalities (n = 59) and those who did not (n = 38). A significant relationship was found between the decrease in FEV1.0 and age; however, no correlation was noted between altered lung function and cigarette smoking, duration of asbestos exposure, or time since last exposure. RAO prevalence was higher (34%) than previously reported (9%) in subjects with chronic obstructive pulmonary disease (COPD) who were not exposed to asbestos or outdoor pollution. The RAO prevalence in asbestos-exposed workers was nearly the same as that measured in COPD subjects who lived downtown and who were exposed to outdoor pollution (36%). The high RAO prevalence in asbestos-exposed workers was found in 43% of subjects who were exposed only to asbestos, and in 33% of subjects who were also exposed to air pollution due to their occupational activities. It is hoped that the observations in this study will encourage practitioners to check for RAO in asbestos workers who use inhaled bronchodilators.
Stephane Delpierre; Marie Jose Delvolgo-Gori; Marion Faucher; Yves Jammes
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of environmental health     Volume:  57     ISSN:  0003-9896     ISO Abbreviation:  Arch. Environ. Health     Publication Date:    2002 Sep-Oct
Date Detail:
Created Date:  2003-03-18     Completed Date:  2003-03-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0212627     Medline TA:  Arch Environ Health     Country:  United States    
Other Details:
Languages:  eng     Pagination:  441-5     Citation Subset:  AIM; IM    
Laboratoire de Physiopathologie Respiratoire, Institut Jean Roche, Faculté de Médecine, Université de la Méditerranée, Marseille, France.
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MeSH Terms
Airway Obstruction / chemically induced*,  diagnosis,  epidemiology
Analysis of Variance
Asbestos / adverse effects*,  analysis
Forced Expiratory Flow Rates
Forced Expiratory Volume
France / epidemiology
Inhalation Exposure / adverse effects*,  analysis
Lung Volume Measurements
Middle Aged
Occupational Diseases / chemically induced*,  diagnosis,  epidemiology
Occupational Exposure / adverse effects*,  analysis
Pulmonary Diffusing Capacity
Respiration Disorders
Retrospective Studies
Risk Factors
Time Factors
Vital Capacity
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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