| High prevalence and phylogenetic analysis of TT-virus infection in Mongolia. | |
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MedLine Citation:
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PMID: 10392725 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A novel DNA virus, TT-virus (TTV), was isolated from a post-transfusion hepatitis patient in Japan. The prevalence of TTV infection was investigated among patients with chronic liver disease and normal alanine aminotransferase (ALT) volunteers as controls in Mongolia. Polymerase chain reaction (PCR) was employed to detect TTV DNA using specific primers derived from open reading frame 1 (ORF1) of the TTV genome. Nucleotide sequences of samples positive for TTV DNA were determined. The sequences were analyzed by a molecular evolutionary method. Fifty (60.2%) hepatitis patients and 12 (42.9%) volunteers were positive for TTV DNA. The serum ALT levels did not differ significantly between patients with single TTV infection and without TTV, HBV and HCV infection. Similarly, the serum ALT levels did not differ significantly between controls with and without TTV infection. Dual infection of TTV with either HBV or HCV did not affect the ALT levels of hepatitis patients. The molecular evolutionary tree showed that TTV was a heterogeneous virus and all strains could be divided into three genotypes in Mongolia. A new genotype was identified that was distinct from those previously reported. |
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Authors:
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H Kato; M Mizokami; T Nakano; Y Kondo; B Dashnyam; T Oyunsuren; R Ueda |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Virus research Volume: 60 ISSN: 0168-1702 ISO Abbreviation: Virus Res. Publication Date: 1999 Apr |
Date Detail:
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Created Date: 1999-08-11 Completed Date: 1999-08-11 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8410979 Medline TA: Virus Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 171-9 Citation Subset: IM |
Affiliation:
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Second Department of Medicine, Nagoya City University Medical School, Kawasumi, Japan. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/AB017881; AB017885; AB017892; AB017893; AB020060; AB020166; AB020167; AB020168; AB020169; AB020170; AB020171; AB020172; AB020173; AB020174; AB020175; AB020176; AB020177; AB020178; AB020179; AB020180; AB020181; AB020182; AB020183; AB020184; AB020185; AF079541; AF079542; AF079543 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alanine Transaminase / blood Base Sequence DNA Virus Infections / epidemiology, genetics* DNA Viruses / genetics* DNA, Viral / chemistry, genetics Evolution, Molecular Female Hepatitis B / blood Hepatitis B Surface Antigens / blood Hepatitis C / blood Hepatitis C Antibodies / blood Hepatitis, Viral, Human / epidemiology, genetics* Humans Male Molecular Sequence Data Mongolia / epidemiology Phylogeny* Prevalence Sequence Alignment Sequence Analysis, DNA Sequence Homology, Nucleic Acid |
| Chemical | |
Reg. No./Substance:
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0/DNA, Viral; 0/Hepatitis B Surface Antigens; 0/Hepatitis C Antibodies; EC 2.6.1.2/Alanine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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