| High prevalence of late relapse and reinfection in prisoners treated for chronic hepatitis C. | |
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MedLine Citation:
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PMID: 20594255 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND AIM: Prisoners have a high prevalence of injection drug use (IDU) and chronic hepatitis C (CHC) infection. Treatment of CHC in these patients is effective; however, their long-term outcomes following treatment are unknown. We determined the durability of a sustained virological response (SVR) in prisoners treated for CHC. METHODS: Patients were treated as part of routine clinical practice with interferon (IFN) and ribavirin. A retrospective review of medical records and a computerized pathology system was performed for clinical and laboratory information. RESULTS: Seventy-four prisoners (70 males, mean age 34 years, IDU in 55%) were evaluable for a SVR over a 12-year period to December 2008; the mean follow-up period was 1243 days. Genotype 1, 2, 3, and 6 infection was present in 18, three, 38 and three patients, respectively; the genotype was unknown in 12. Three out of 52 biopsied had cirrhosis. Standard IFN was administered to 25 (34%; 11 with ribavirin), and 49 received pegylated IFN and ribavirin; one did not complete treatment, and two had breakthrough relapses. The end-of-treatment response was achieved in 57 and SVR in 53; 14 were non-responders. Five male patients, four with unknown genotypes and treated with standard IFN alone, relapsed late (following SVR, 9%). Five patients, all treated with pegylated IFN and ribavirin, were reinfected (one prior to and four following SVR). CONCLUSIONS: Prisoners are often successfully treated for CHC. However, this retrospective study indicates that there is a high (17%) prevalence of late recurrence of viremia that is likely a reflection of reinfection due to ongoing risk-taking behavior. |
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Authors:
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John P Bate; Anton J Colman; Peter J Frost; David R Shaw; Hugh A J Harley |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of gastroenterology and hepatology Volume: 25 ISSN: 1440-1746 ISO Abbreviation: J. Gastroenterol. Hepatol. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-02 Completed Date: 2010-10-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8607909 Medline TA: J Gastroenterol Hepatol Country: Australia |
Other Details:
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Languages: eng Pagination: 1276-80 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology and Hepatology, Royal Adelaide Hospital, Adelaide, South Australia, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antiviral Agents / therapeutic use* Drug Therapy, Combination Drug Users* / statistics & numerical data Female Hepacivirus / genetics Hepatitis C, Chronic / diagnosis, drug therapy*, epidemiology, transmission Humans Interferons / therapeutic use Male Prevalence Prisoners* / statistics & numerical data RNA, Viral / blood Recurrence Retrospective Studies Ribavirin / therapeutic use South Australia / epidemiology Substance Abuse, Intravenous / complications*, epidemiology Time Factors Treatment Outcome Viral Load |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 0/RNA, Viral; 36791-04-5/Ribavirin; 9008-11-1/Interferons |
| Comments/Corrections | |
Comment In:
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J Gastroenterol Hepatol. 2010 Jul;25(7):1184-6
[PMID:
20594243
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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