| High prevalence of hypothyroidism in patients with primary pulmonary hypertension. | |
| | |
MedLine Citation:
|
PMID: 10555089 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: To characterize the prevalence of hypothyroidism in a population with primary pulmonary hypertension (PPH). METHODS: Retrospective record review of 41 patients with PPH seen between 1991 and 1997 at a tertiary care center. Data abstracted included: history of previous thyroid disease, intake of thyroid supplement, and thyroid function tests. Hypothyroidism was defined as a serum thyroid stimulating hormone (TSH) level higher than 5.5 U/L, intake of thyroid supplement, or low serum thyroxine level. RESULTS: Of the 40 patients with PPH included in the study (11 men and 29 women), ages ranged from 11 to 76 years (mean 43.5 years). The mean pulmonary artery pressure was 58.7 mm Hg. Thirty-three patients had normal serum TSH levels (3 of whom were on levothyroxine supplement); 1 had low TSH; 5 had high TSH (range, 6.8-9.9 U/L, mean 8.4 U/L), and 1 had low thyroxine (T4 < 1.0 microg/dL). Nine of 40 patients (22.5%) had evidence of hypothyroidism, which is much more than expected in the general population of similar age range (2.8% in men, 7.5% in women) (p = 0.002). CONCLUSIONS: The prevalence of hypothyroidism in patients with PPH is high (22.5%). Patients with PPH should be investigated for the possibility of coexisting hypothyroidism. |
| | |
Authors:
|
A L Curnock; R A Dweik; B H Higgins; H F Saadi; A C Arroliga |
Related Documents
:
|
2411889 - Diagnosis and management of large toxic multinodular goiters. 8965149 - Stability of values for thyroid radioiodine uptake. 698489 - A study of thyroid function in psychiatric in-patients. 11484889 - Effects of thyroid hormones on cardiac structure: a tissue characterization study in pa... 7411659 - Free t4, free t3, and reverse t3 in critically ill, thermally injured patients. 2479309 - Thyrotropin-secreting pituitary adenomas: clinical and biochemical heterogeneity. case ... 18022499 - Radiologic diagnoses of patients who received imaging for venous thromboembolism despit... 1173749 - Lymphosarcoma of the right atrium. angiographic and hemodynamic documentation of respon... 3509599 - Symptomatic internal carotid thrombosis after carotid endarterectomy. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The American journal of the medical sciences Volume: 318 ISSN: 0002-9629 ISO Abbreviation: Am. J. Med. Sci. Publication Date: 1999 Nov |
Date Detail:
|
Created Date: 1999-11-16 Completed Date: 1999-11-16 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0370506 Medline TA: Am J Med Sci Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 289-92 Citation Subset: AIM; IM |
Affiliation:
|
Department of General Internal Medicine, The Cleveland Clinic Foundation, Ohio 44195, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Child Female Humans Hypertension, Pulmonary / blood, complications* Hypothyroidism / blood, epidemiology, etiology* Male Medical Records Middle Aged Prevalence Retrospective Studies Risk Factors Thyrotropin / blood Thyroxine / blood |
| Chemical | |
Reg. No./Substance:
|
7488-70-2/Thyroxine; 9002-71-5/Thyrotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Histological effects of iron accumulation on mice liver and spleen after administration of a metalli...
Next Document: Pulmonary physiologic changes of morbid obesity.