Document Detail

High prevalence of hypothyroidism in patients with primary pulmonary hypertension.
MedLine Citation:
PMID:  10555089     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To characterize the prevalence of hypothyroidism in a population with primary pulmonary hypertension (PPH). METHODS: Retrospective record review of 41 patients with PPH seen between 1991 and 1997 at a tertiary care center. Data abstracted included: history of previous thyroid disease, intake of thyroid supplement, and thyroid function tests. Hypothyroidism was defined as a serum thyroid stimulating hormone (TSH) level higher than 5.5 U/L, intake of thyroid supplement, or low serum thyroxine level. RESULTS: Of the 40 patients with PPH included in the study (11 men and 29 women), ages ranged from 11 to 76 years (mean 43.5 years). The mean pulmonary artery pressure was 58.7 mm Hg. Thirty-three patients had normal serum TSH levels (3 of whom were on levothyroxine supplement); 1 had low TSH; 5 had high TSH (range, 6.8-9.9 U/L, mean 8.4 U/L), and 1 had low thyroxine (T4 < 1.0 microg/dL). Nine of 40 patients (22.5%) had evidence of hypothyroidism, which is much more than expected in the general population of similar age range (2.8% in men, 7.5% in women) (p = 0.002). CONCLUSIONS: The prevalence of hypothyroidism in patients with PPH is high (22.5%). Patients with PPH should be investigated for the possibility of coexisting hypothyroidism.
A L Curnock; R A Dweik; B H Higgins; H F Saadi; A C Arroliga
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of the medical sciences     Volume:  318     ISSN:  0002-9629     ISO Abbreviation:  Am. J. Med. Sci.     Publication Date:  1999 Nov 
Date Detail:
Created Date:  1999-11-16     Completed Date:  1999-11-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370506     Medline TA:  Am J Med Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  289-92     Citation Subset:  AIM; IM    
Department of General Internal Medicine, The Cleveland Clinic Foundation, Ohio 44195, USA.
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MeSH Terms
Hypertension, Pulmonary / blood,  complications*
Hypothyroidism / blood,  epidemiology,  etiology*
Medical Records
Middle Aged
Retrospective Studies
Risk Factors
Thyrotropin / blood
Thyroxine / blood
Reg. No./Substance:
7488-70-2/Thyroxine; 9002-71-5/Thyrotropin

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