| High prevalence of hepatic focal nodular hyperplasia in subjects with hereditary hemorrhagic telangiectasia. | |
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MedLine Citation:
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PMID: 15550313 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A vascular pathogenesis of hepatic focal nodular hyperplasia (FNH) has been suggested; this study was aimed to evaluate in families with hereditary hemorrhagic telangiectasia (HHT) the prevalence of FNH, relating it to presence and stage of hepatic vascular malformations (VMs). Fifty-two HHT families underwent a screening program including abdominal Doppler sonography (US) searching for hepatic VMs; we classified them as minimal, moderate and severe, depending on the number and degree of abnormalities found by Doppler US. Presence of focal liver lesions was recorded. Diagnosis of FNH was made if at least two examinations, whether color Doppler US, liver scintigraphy, dynamic computed tomography (CT) or magnetic resonance (MR), showed suggestive findings. FNH was found in five out of 274 subjects (1.8%). All five were affected by HHT. Thus, percentage related to the group of affected patients increased to 2.9; 4/5 presented severe liver VMs. Female-to-male ratio was 4:1. FNH was single in three cases; tumor size ranged between 20 and 90 mm. During follow-up, no lesion showed a reduction in size, three showed an increase. Prevalence of FNH in patients with HHT is far greater than that reported in the general population; Doppler US role in its diagnosis and follow-up is highlighted. |
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Authors:
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Elisabetta Buscarini; Cesare Danesino; Henry Plauchu; Cristina de Fazio; Carla Olivieri; Gianfranco Brambilla; Fernanda Menozzi; Luigi Reduzzi; Pasquale Blotta; Pietro Gazzaniga; Fabio Pagella; Maurizio Grosso; Giacomo Pongiglione; Johnny Cappiello; Alessandro Zambelli |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Ultrasound in medicine & biology Volume: 30 ISSN: 0301-5629 ISO Abbreviation: Ultrasound Med Biol Publication Date: 2004 Sep |
Date Detail:
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Created Date: 2004-11-19 Completed Date: 2005-03-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0410553 Medline TA: Ultrasound Med Biol Country: England |
Other Details:
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Languages: eng Pagination: 1089-97 Citation Subset: IM |
Affiliation:
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Gastroenterology Department, Ospedale Maggiore, Crema, Italy. ebuscarini@rim.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Arteriovenous Malformations / epidemiology, ultrasonography Family Health Female Focal Nodular Hyperplasia / epidemiology, ultrasonography* Hemangioma / complications, ultrasonography Hepatic Artery / abnormalities Humans Liver / ultrasonography Liver Neoplasms / epidemiology, ultrasonography Male Middle Aged Sex Distribution Telangiectasia, Hereditary Hemorrhagic / epidemiology, ultrasonography* Ultrasonography, Doppler |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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