Document Detail


High prevalence of aeroallergen sensitization among infants of atopic parents.
MedLine Citation:
PMID:  17011322     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To present methodology to identify atopic parents and determine the prevalence of sensitization to 15 aeroallergens in their infant offspring.
STUDY DESIGN: A birth cohort of infants was identified from birth records; an infant was enrolled if 1 of the parents reported allergy respiratory symptoms and had a positive skin prick test (SPT) to a common aeroallergen. At age 1 year, these infants were tested to the same aeroallergens.
RESULTS: Of the 680 enrolled infants, 28.4% were SPT+ to 1 or more aeroallergens and/or food, and 18.0% were positive to 1 or more aeroallergens. By category of allergens, 9.7% were sensitized to pollens, 7.5% to molds, 4.3% to house dust mite and/or cockroach, and 3.4% to dog and/or cat. Of the infants who were positive to an aeroallergen, 65.7% remained positive at age 2 years.
CONCLUSIONS: Infants born to atopic parents with percutaneous sensitization to aeroallergens are at increased risk for aeroallergen sensitization during infancy, which persists to age 2 years. These findings suggest that current clinical practices, which generally avoid skin testing before age 2 years, be reassessed in this population of high-risk children.
Authors:
Grace K LeMasters; Kimberly Wilson; Linda Levin; Jocelyn Biagini; Patrick Ryan; James E Lockey; Sherry Stanforth; Stephanie Maier; Jun Yang; Jeff Burkle; Manuel Villareal; Gurjit K Khurana Hershey; David I Bernstein
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  149     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-02     Completed Date:  2006-11-28     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  505-11     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Allergens / adverse effects
Family Health*
Female
Humans
Hypersensitivity, Immediate / epidemiology*
Infant
Male
Parents
Prevalence
Questionnaires
Respiratory Hypersensitivity / epidemiology*,  immunology
Skin Tests
Grant Support
ID/Acronym/Agency:
ES10957/ES/NIEHS NIH HHS; ES11170/ES/NIEHS NIH HHS; R01 ES011170/ES/NIEHS NIH HHS; R01 ES011170-05/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Allergens
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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