| High prevalence of acute myocardial damage in a hospital necropsy series, shown by C9 immunohistology. | |
| | |
MedLine Citation:
|
PMID: 9797737 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIMS: To use a sensitive test of acute myocardial damage--immunohistological detection of complement component C9--to assess the prevalence of damage in an unselected series of hearts taken at necropsy in adults. METHODS: Sections of formalin fixed and paraffin wax embedded myocardium were cut from 128 consecutive necropsy cases on which a block of heart had been taken. These were stained with an immunohistological method for C9. Necropsy findings were reviewed and clinical risk factors for myocardial damage noted. The extent of C9 immunostaining was correlated with clinical and pathological findings. RESULTS: There was immunostaining for C9 in 109 heart sections (85%). Most had conventional evidence of coronary artery disease or acute or chronic myocardial abnormality, but necrosis was identified by orthodox microscopy in only 12 (11% of C9 positive cases). In 29 cases, orthodox examination showed no abnormality, but C9 was detected. These cases had clinical risk factors for damage such as hypoxia and hypotension. Increasing age, heart weight, and total number of risk factors and pathological findings were associated with increasing extent of C9 immunostaining. CONCLUSIONS: Acute myocardial damage was common in a hospital necropsy series and its prevalence was underestimated by conventional pathological techniques. Immunostaining for C9 was a simple and useful way of detecting such damage. |
| | |
Authors:
|
M A Ferreira; H E Owen; A J Howie |
Related Documents
:
|
648217 - Dissociation of the atrioventricular node in acute inferior wall myocardial infarction.... 624317 - Selective coronary angiography in patients with conduction disturbances of the heart. 2661547 - Depression, heart disease, and tricyclic antidepressants. 14163807 - Reversible cold block of the specialized cardiac tissues of the unanaesthetized dog. 14609607 - Comparison of effectiveness of implantable cardioverter defibrillator in patients with ... 8110627 - Thrombolytic agents and anticoagulants. |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Journal of clinical pathology Volume: 51 ISSN: 0021-9746 ISO Abbreviation: J. Clin. Pathol. Publication Date: 1998 Jul |
Date Detail:
|
Created Date: 1998-11-09 Completed Date: 1998-11-09 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 0376601 Medline TA: J Clin Pathol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 548-51 Citation Subset: AIM; IM |
Affiliation:
|
Department of Pathology, University of Birmingham, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acute Disease Aged Autopsy Biological Markers / analysis Cardiomyopathies / immunology, pathology* Complement C9 / analysis* Humans Immunohistochemistry Middle Aged Myocardium / immunology, pathology* Prevalence Retrospective Studies |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/Complement C9 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Improved FNA cytology results with a near patient diagnosis service for non-breast lesions.
Next Document: Myoepithelial carcinoma (malignant myoepithelioma) of the parotid gland arising in a pleomorphic ade...