Document Detail


High prevalence of Mycobacterium tuberculosis DNA in biopsies from sarcoidosis patients from Catalonia, Spain.
MedLine Citation:
PMID:  16113515     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Sarcoidosis is a systemic granulomatous disease of unknown etiology. The presence of mycobacterial nucleic acid components in patients with sarcoidosis has been demonstrated with varying degrees of success. OBJECTIVES: The aim of this study was to estimate the presence of Mycobacterium tuberculosis DNA in tissues from sarcoidosis patients, in Catalonia, Spain, as well as to assess the long-term clinical course in these patients. METHODS: Fifty-eight paraffin-embedded tissue biopsies corresponding to cases of sarcoidosis (n = 23), lung neoplasm (n = 23), and lung tuberculosis (n = 12) available in 1996 were analyzed in a retrospective study by means of a nested polymerase chain reaction using primers corresponding to the insertion element IS6110 of M. tuberculosis complex. For greater sensitivity, Southern blot hybridization was performed. Clinical data were recorded prior to and after PCR analysis (follow-up reported until 2002). RESULTS: M. tuberculosis DNA was present in 9 out of 23 sarcoidosis biopsies (39%), in 1 out of 23 control patients (4%) (p < 0.01), and in all tissue samples from the 12 control patients with tuberculosis. To date, none of these sarcoidosis patients has developed tuberculosis over a mean (+/-SD) follow-up period of 11 (+/-3.4) years. CONCLUSION: In our setting, M. tuberculosis DNA is present in tissue biopsies of significantly more sarcoidosis patients than controls. However, these results do not demonstrate causality, although they may suggest a link between M. tuberculosis infection and sarcoidosis in some cases. Follow-up of these patients suggests that M. tuberculosis-DNA-positive sarcoidosis patients are not at greater risk of developing tuberculosis than M. tuberculosis-DNA-negative patients.
Authors:
E Fité; M T Fernández-Figueras; R Prats; M Vaquero; J Morera
Related Documents :
20977495 - X-linked agammaglobulinemia complicated with endobronchial tuberculosis.
8310395 - Ocular tuberculosis.
12588015 - Exogenous re-infection as a cause of recurrent tuberculosis in a low-incidence area.
16325875 - Smoking and tuberculosis: the epidemiological association and immunopathogenesis.
1735355 - Adult "idiopathic" extrahepatic venous thrombosis. importance of putative "latent" myel...
2031465 - Diagnosing personality disorders in psychiatric inpatients.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-08-17
Journal Detail:
Title:  Respiration; international review of thoracic diseases     Volume:  73     ISSN:  0025-7931     ISO Abbreviation:  Respiration     Publication Date:  2006  
Date Detail:
Created Date:  2006-03-01     Completed Date:  2006-06-15     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0137356     Medline TA:  Respiration     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  20-6     Citation Subset:  IM    
Copyright Information:
Copyright 2006 S. Karger AG, Basel.
Affiliation:
Servei de Pneumologia, Hospital Universitari Germans Trias i Pujol, Universitat Autonoma de Barcelona, Badalona, Spain. 9033efr@comb.es
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Antigens, Bacterial / immunology
Case-Control Studies
Comorbidity
DNA, Bacterial / analysis*
Female
Genetic Predisposition to Disease
Humans
Male
Middle Aged
Mycobacterium tuberculosis / genetics*,  immunology
Sarcoidosis / epidemiology*,  genetics,  immunology,  microbiology*
Spain / epidemiology
Tuberculosis / epidemiology*
Chemical
Reg. No./Substance:
0/Antigens, Bacterial; 0/DNA, Bacterial
Comments/Corrections
Comment In:
Respiration. 2006;73(1):14-5   [PMID:  16498268 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Outcomes of adults with cystic fibrosis infected with antibiotic-resistant Pseudomonas aeruginosa.
Next Document:  Analysis of forced wheezes in asthma patients.