Document Detail

High prevalence of IgA rheumatoid factor in severe polyarticular-onset juvenile rheumatoid arthritis, but not in systemic-onset or pauciarticular-onset disease.
MedLine Citation:
PMID:  2306290     Owner:  NLM     Status:  MEDLINE    
The presence of IgA rheumatoid factor (IgA-RF) has been correlated with severe joint disease in adult rheumatoid arthritis (RA), but IgA-RF has not been reported in juvenile rheumatoid arthritis (JRA). In the present study, IgA-RF was assayed by an enzyme-linked immunosorbent assay and was found in the sera of 14 of 24 children (58%) with active polyarticular JRA. The presence of IgA-RF correlated with the degree of functional disability. In contrast, IgA-RF was not found in the sera of systemic-onset disease patients, regardless of the degree of dysfunction. IgA-RF was detected in only 1 patient with pauciarticular disease, despite the fact that several patients in this group had severe disease. The presence of IgA-RF in polyarticular JRA did not correlate with serum IgA levels, but did correlate with the presence and the level of serum IgM-RF. Thus, the presence of IgA-RF appears to be specific for polyarticular JRA, and shows a correlation with severe disease in this group.
S M Walker; D K McCurdy; B Shaham; R Brik; H Wietting; Y Arora; T J Lehman; V Hanson; B Bernstein
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Arthritis and rheumatism     Volume:  33     ISSN:  0004-3591     ISO Abbreviation:  Arthritis Rheum.     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-03-23     Completed Date:  1990-03-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370605     Medline TA:  Arthritis Rheum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  199-204     Citation Subset:  AIM; IM    
Department of Pediatrics, Childrens Hospital of Los Angeles, University of Southern California 90027.
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MeSH Terms
Arthritis, Rheumatoid / classification,  immunology*
Cell Separation
Cells, Cultured
Child, Preschool
Enzyme-Linked Immunosorbent Assay
Immunoglobulin A / analysis*
Immunoglobulin Fab Fragments / analysis
Immunoglobulin Fc Fragments / analysis
Immunoglobulin G / analysis
Rheumatoid Factor / analysis*
Reg. No./Substance:
0/Immunoglobulin A; 0/Immunoglobulin Fab Fragments; 0/Immunoglobulin Fc Fragments; 0/Immunoglobulin G; 9009-79-4/Rheumatoid Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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