Document Detail

High pressure study of molecular dynamics of protic ionic liquid lidocaine hydrochloride.
MedLine Citation:
PMID:  22713051     Owner:  NLM     Status:  In-Data-Review    
In this paper, we investigate the effect of pressure on the molecular dynamics of protic ionic liquid lidocaine hydrochloride, a commonly used pharmaceutical, by means of dielectric spectroscopy and pressure-temperature-volume methods. We observed that near T(g) the pressure dependence of conductivity relaxation times reveals a peculiar behavior, which can be treated as a manifestation of decoupling between ion migration and structural relaxation times. Moreover, we discuss the validity of thermodynamic scaling in lidocaine HCl. We also employed the temperature-volume Avramov model to determine the value of pressure coefficient of glass transition temperature, dT(g)∕dP∣(P = 0.1). Finally, we investigate the role of thermal and density fluctuations in controlling of molecular dynamics of the examined compound.
A Swiety-Pospiech; Z Wojnarowska; J Pionteck; S Pawlus; A Grzybowski; S Hensel-Bielowka; K Grzybowska; A Szulc; M Paluch
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of chemical physics     Volume:  136     ISSN:  1089-7690     ISO Abbreviation:  J Chem Phys     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375360     Medline TA:  J Chem Phys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  224501     Citation Subset:  IM    
Institute of Physics, University of Silesia, ul. Uniwersytecka 4, 40-007 Katowice, Poland.
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