| High-pressure liquid chromatographic analysis of drugs in biological fluids. IV. Determination of clofibrinic acid. | |
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MedLine Citation:
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PMID: 893579 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A rapid, sensitive and specific high-pressure liquid chromatographic method is described for the quantitative analysis of clofibrinic acid in plasma, saliva and urine. In contrast to previously reported gas-liquid chromatographic methods, which require derivatization of clofibrinic acid before chromatography, the present method involves a simple two-step extraction procedure and chromatographic determination of the underivatized clofibrinic acid. Concentrations between 1.0 and 25.0 microgram per sample can be measured with a coefficient of variation from 1 to 6%. |
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Authors:
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T D Bjornsson; T F Blaschke; P J Meffin |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of chromatography Volume: 137 ISSN: 0021-9673 ISO Abbreviation: J. Chromatogr. Publication Date: 1977 Jul |
Date Detail:
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Created Date: 1977-10-14 Completed Date: 1977-10-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0427043 Medline TA: J Chromatogr Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 145-52 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chromatography, High Pressure Liquid
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methods Clofibrate / analogs & derivatives*, analysis, blood, urine Humans Male Saliva / analysis Time Factors |
| Chemical | |
Reg. No./Substance:
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637-07-0/Clofibrate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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