Document Detail

High pressure, diazepam and pH influences on ketamine anaesthesia in the rat.
MedLine Citation:
PMID:  7468119     Owner:  NLM     Status:  MEDLINE    
Ketamine infusion anaesthesia was studied in rats breathing oxygen/helium under hyperbaric conditions from 1 to 90 ATA. No pressure reversal of the analgesic effect was found. Premedication with diazepam failed to improve the analgesic action of ketamine, but influenced the respiratory pattern. Blood-gas analyses showed a marked relationship between arterial pH and the ketamine dose requirement for stable anaesthesia.
L Gran; P Kaufmann; P B Bennett
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  24     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  1980 Aug 
Date Detail:
Created Date:  1981-04-13     Completed Date:  1981-04-13     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  310-3     Citation Subset:  IM    
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MeSH Terms
Diazepam / pharmacology*
Hydrogen-Ion Concentration
Preanesthetic Medication
Reg. No./Substance:
439-14-5/Diazepam; 6740-88-1/Ketamine; 76-75-5/Thiopental

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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