| High-pressure on-chip mechanical valves for thermoplastic microfluidic devices. | |
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MedLine Citation:
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PMID: 20024030 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A facile method enabling the integration of elastomeric valves into rigid thermoplastic microfluidic chips is described. The valves employ discrete plugs of elastomeric polydimethylsiloxane (PDMS) integrated into the thermoplastic substrate and actuated using a threaded stainless steel needle. The fabrication process takes advantage of poly(ethylene glycol) (PEG) as a sacrificial molding material to isolate the PDMS regions from the thermoplastic flow channels, while yielding smooth contact surfaces with the PDMS valve seats. The valves introduce minimal dead volumes, and provide a simple mechanical means to achieve reproducible proportional valving within thermoplastic microfluidic systems. Burst pressure tests reveal that the valves can withstand pressures above 12 MPa over repeated open/close cycles without leakage, and above 24 MPa during a single use, making the technology well suited for applications such as high performance liquid chromatography. Proportional valve operation is demonstrated using a multi-valve chemical gradient generator fabricated in cyclic olefin polymer. |
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Authors:
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Chien-Fu Chen; Jikun Liu; Chien-Cheng Chang; Don L DeVoe |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-10-06 |
Journal Detail:
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Title: Lab on a chip Volume: 9 ISSN: 1473-0197 ISO Abbreviation: Lab Chip Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-12-21 Completed Date: 2010-01-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101128948 Medline TA: Lab Chip Country: England |
Other Details:
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Languages: eng Pagination: 3511-6 Citation Subset: IM |
Affiliation:
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Department of Mechanical Engineering, Department of Bioengineering, University of Maryland, College Park, MD, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alkenes
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chemistry Dimethylpolysiloxanes / chemistry Gases / chemistry Mechanical Processes* Microfluidic Analytical Techniques / instrumentation* Microtechnology Permeability Polyethylene Glycols / chemistry Polymers / chemistry* Pressure* Solvents / chemistry Surface Properties Temperature* |
| Grant Support | |
ID/Acronym/Agency:
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R01 GM072512/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Alkenes; 0/Dimethylpolysiloxanes; 0/Gases; 0/Polyethylene Glycols; 0/Polymers; 0/Solvents; 63148-62-9/baysilon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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