| High pregnancy anxiety during mid-gestation is associated with decreased gray matter density in 6-9-year-old children. | |
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MedLine Citation:
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PMID: 19674845 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Because the brain undergoes dramatic changes during fetal development it is vulnerable to environmental insults. There is evidence that maternal stress and anxiety during pregnancy influences birth outcome but there are no studies that have evaluated the influence of stress during human pregnancy on brain morphology. In the current prospective longitudinal study we included 35 women for whom serial data on pregnancy anxiety was available at 19 (+/-0.83), 25 (+/-0.9) and 31 (+/-0.9) weeks gestation. When the offspring from the target pregnancy were between 6 and 9 years of age, their neurodevelopmental stage was assessed by a structural MRI scan. With the application of voxel-based morphometry, we found regional reductions in gray matter density in association with pregnancy anxiety after controlling for total gray matter volume, age, gestational age at birth, handedness and postpartum perceived stress. Specifically, independent of postnatal stress, pregnancy anxiety at 19 weeks gestation was associated with gray matter volume reductions in the prefrontal cortex, the premotor cortex, the medial temporal lobe, the lateral temporal cortex, the postcentral gyrus as well as the cerebellum extending to the middle occipital gyrus and the fusiform gyrus. High pregnancy anxiety at 25 and 31 weeks gestation was not significantly associated with local reductions in gray matter volume.This is the first prospective study to show that a specific temporal pattern of pregnancy anxiety is related to specific changes in brain morphology. Altered gray matter volume in brain regions affected by prenatal maternal anxiety may render the developing individual more vulnerable to neurodevelopmental and psychiatric disorders as well as cognitive and intellectual impairment. |
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Authors:
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Claudia Buss; Elysia Poggi Davis; L Tugan Muftuler; Kevin Head; Curt A Sandman |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Psychoneuroendocrinology Volume: 35 ISSN: 1873-3360 ISO Abbreviation: Psychoneuroendocrinology Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-17 Completed Date: 2010-02-24 Revised Date: 2011-07-19 |
Medline Journal Info:
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Nlm Unique ID: 7612148 Medline TA: Psychoneuroendocrinology Country: England |
Other Details:
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Languages: eng Pagination: 141-53 Citation Subset: IM |
Affiliation:
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Department of Psychiatry and Human Behavior, University of California, Irvine, Orange, CA 92868, United States. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anxiety / pathology*, psychology Brain / growth & development*, pathology* Child Female Gestational Age Humans Longitudinal Studies Magnetic Resonance Imaging Male Postpartum Period / psychology Pregnancy Pregnancy Complications / pathology*, psychology Prenatal Exposure Delayed Effects / pathology* Prospective Studies Risk Socioeconomic Factors |
| Grant Support | |
ID/Acronym/Agency:
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HD-51852/HD/NICHD NIH HHS; HD28413/HD/NICHD NIH HHS; NS-41298/NS/NINDS NIH HHS; R01 HD028413-08/HD/NICHD NIH HHS; R01 HD051852-04/HD/NICHD NIH HHS; R01 NS041298-05/NS/NINDS NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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