Document Detail


High precision isotope measurements reveal poor control of copper metabolism in parkinsonism.
MedLine Citation:
PMID:  23340956     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Disordered copper metabolism may be important in the aetiology of Parkinsonism, as caeruloplasmin is a key enzyme in handling oxidative stress and is involved in the synthesis pathway of dopamine. The human Cu metabolism of ten Parkinsonism patients was compared to ten healthy controls with the aid of a stable (65)Cu isotope tracer. The analyses of blood serum (65)Cu/(63)Cu ratios yielded individual isotopic profiles, which indicate that the Cu metabolism is less controlled in patients with Parkinsonism. Modelling based on both isotope tracer and total Cu concentrations suggests that 30% of the subjects affected by Parkinsonism have abnormally large Cu stores in tissues. To detect the small differences in Cu metabolism between Parkinsonism and controls, the analysis of stable isotope composition must be performed using multiple-collector inductively coupled plasma mass spectrometry and the associated sample preparation techniques. This pilot investigation supports full-scale medical studies into the Cu metabolism of those with Parkinsonism.
Authors:
F Larner; B Sampson; M Rehkämper; D J Weiss; J R Dainty; S O'Riordan; T Panetta; P G Bain
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-23
Journal Detail:
Title:  Metallomics : integrated biometal science     Volume:  5     ISSN:  1756-591X     ISO Abbreviation:  Metallomics     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-31     Completed Date:  2013-07-12     Revised Date:  2013-07-19    
Medline Journal Info:
Nlm Unique ID:  101478346     Medline TA:  Metallomics     Country:  England    
Other Details:
Languages:  eng     Pagination:  125-32     Citation Subset:  IM    
Affiliation:
Department of Earth Science & Engineering, Imperial College, London, UK. fiona.larner@earth.ox.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Copper / blood*
Humans
Isotopes / blood*
Middle Aged
Parkinsonian Disorders / blood*
Chemical
Reg. No./Substance:
0/Isotopes; 7440-50-8/Copper

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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