Document Detail

High-power, computer-controlled, light-emitting diode-based light sources for fluorescence imaging and image-guided surgery.
MedLine Citation:
PMID:  19723473     Owner:  NLM     Status:  MEDLINE    
Optical imaging requires appropriate light sources. For image-guided surgery, in particular fluorescence-guided surgery, a high fluence rate, a long working distance, computer control, and precise control of wavelength are required. In this article, we describe the development of light-emitting diode (LED)-based light sources that meet these criteria. These light sources are enabled by a compact LED module that includes an integrated linear driver, heat dissipation technology, and real-time temperature monitoring. Measuring only 27 mm wide by 29 mm high and weighing only 14.7 g, each module provides up to 6,500 lx of white (400-650 nm) light and up to 157 mW of filtered fluorescence excitation light while maintaining an operating temperature < or = 50 degrees C. We also describe software that can be used to design multimodule light housings and an embedded processor that permits computer control and temperature monitoring. With these tools, we constructed a 76-module, sterilizable, three-wavelength surgical light source capable of providing up to 40,000 lx of white light, 4.0 mW/cm2 of 670 nm near-infrared (NIR) fluorescence excitation light, and 14.0 mW/cm2 of 760 nm NIR fluorescence excitation light over a 15 cm diameter field of view. Using this light source, we demonstrated NIR fluorescence-guided surgery in a large-animal model.
Sylvain Gioux; Vida Kianzad; Razvan Ciocan; Sunil Gupta; Rafiou Oketokoun; John V Frangioni
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular imaging     Volume:  8     ISSN:  1535-3508     ISO Abbreviation:  Mol Imaging     Publication Date:    2009 May-Jun
Date Detail:
Created Date:  2009-09-02     Completed Date:  2009-10-06     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  101120118     Medline TA:  Mol Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  156-65     Citation Subset:  IM    
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MeSH Terms
Diagnostic Imaging / instrumentation*
Equipment Design
Finite Element Analysis
Optics and Photonics / instrumentation*
Spectrometry, Fluorescence / instrumentation*
Spectroscopy, Near-Infrared / instrumentation
Surgery, Computer-Assisted / instrumentation*
Grant Support
R01 CA115296/CA/NCI NIH HHS; R01 CA115296-04/CA/NCI NIH HHS; R01-CA-115296/CA/NCI NIH HHS

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