| High plasma lecithin:cholesterol acyltransferase activity does not predict low incidence of cardiovascular events: possible attenuation of cardioprotection associated with high HDL cholesterol. | |
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MedLine Citation:
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PMID: 19698944 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cholesterol esterifying enzyme, lecithin:cholesterol acyltransferase (LCAT), is crucial in high density lipoprotein (HDL) metabolism. The role of LCAT activity on incident cardiovascular disease (CVD) is unknown. We determined the association of incident CVD with plasma LCAT activity, and evaluated whether LCAT may modify the cardioprotective effect of higher HDL cholesterol. In a community-based prospective nested case-control study (PREVEND cohort), an exogenous substrate assay was used to measure plasma LCAT activity in 116 men who developed CVD (cases) and in 111 male controls. Plasma LCAT activity was 5% higher in cases (P=0.027) in association with higher total cholesterol, non-HDL cholesterol and triglycerides. Age-adjusted incident CVD was increased with higher LCAT activity (continuous variable: hazard ratio (HR) 1.23; 95% CI 1.01-1.49, P=0.037; upper quartile vs. lowest 3 quartiles: HR 1.60; 95% CI 1.07-2.39, P=0.021). This relationship was not significant after adjustment for lipids. Compared to subjects with HDL cholesterol above the median and lower LCAT activity (lowest 3 quartiles) the age-adjusted cardiovascular risk was elevated in subjects with similarly higher HDL cholesterol and higher LCAT activity (HR 2.38; 95% CI 1.27-4.49, P=0.007), lower HDL cholesterol and lower LCAT activity (HR 2.58; 95% CI 1.64-4.49, P<0.001) and lower HDL cholesterol and higher LCAT activity (HR 2.76; 95% CI 1.58-4.83, P<0.001). These HRs were unchanged after non-HDL cholesterol and triglyceride adjustment. In conclusion, high plasma LCAT activity does not predict reduced CVD risk, and may attenuate cardioprotection associated with higher HDL cholesterol. |
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Authors:
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Robin P F Dullaart; Frank Perton; Melanie M van der Klauw; Hans L Hillege; Wim J Sluiter; |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-07-30 |
Journal Detail:
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Title: Atherosclerosis Volume: 208 ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-01 Completed Date: 2010-04-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
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Languages: eng Pagination: 537-42 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Endocrinology, University of Groningen and University Medical Center Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands. r.p.f.dullaart@int.umcg.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cardiovascular Diseases / blood*, epidemiology*, prevention & control Case-Control Studies Cholesterol, HDL / metabolism* Cohort Studies Gene Expression Regulation, Enzymologic Humans Incidence Male Middle Aged Phosphatidylcholine-Sterol O-Acyltransferase / blood* Proportional Hazards Models Prospective Studies Triglycerides / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Triglycerides; EC 2.3.1.43/Phosphatidylcholine-Sterol O-Acyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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