| High plasma aldosterone and low renin predict blood pressure increase and hypertension in middle-aged Caucasian populations. | |
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MedLine Citation:
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PMID: 18449201 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Plasma aldosterone and renin levels have been associated with blood pressure increase and 3-4 year incidence of hypertension in a middle-aged North American community in Framingham. To confirm these findings in a different population, a nested case-control study was performed in a national sample of 1984 French non-hypertensive volunteers aged 45-64 year and followed for 5 years. Cases and controls (individuals becoming hypertensive or remaining non-hypertensive on follow-up) were individually matched on sex, diastolic and systolic pressures at baseline. Multivariable regression models show that plasma aldosterone and renin are respectively positively and negatively associated with the increase in systolic pressure (P=0.01 and 0.001) and the risk of hypertension (22% increase and 16% decrease per s.d. increment in the log, P=0.04 and 0.07). These associations are mostly observed in the lowest tertiles of dietary sodium and potassium intakes where plasma aldosterone is positively associated with the increase in systolic pressure (P=0.01 and 0.08) and the risk of hypertension (59 and 69% increase per s.d. increment in the log, P=0.02 and 0.01), whereas plasma renin is negatively associated with the increase in systolic pressure (P=0.0004 and 0.004) and the risk of hypertension (31 and 28% decrease per s.d. increment in the log, P=0.03 and 0.05). These results reinforce the hypothesis that high plasma aldosterone and low plasma renin levels precede blood pressure increase and the occurrence of hypertension in middle-aged Caucasian populations. |
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Authors:
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P Meneton; P Galan; S Bertrais; D Heudes; S Hercberg; J Ménard |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-05-01 |
Journal Detail:
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Title: Journal of human hypertension Volume: 22 ISSN: 0950-9240 ISO Abbreviation: J Hum Hypertens Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-07-17 Completed Date: 2008-12-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8811625 Medline TA: J Hum Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 550-8 Citation Subset: IM |
Affiliation:
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INSERM U872, Centre de Recherche des Cordeliers, Paris, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aldosterone / blood* Blood Pressure / physiology* European Continental Ancestry Group* Female Follow-Up Studies France / epidemiology Humans Hypertension / blood*, ethnology, physiopathology Incidence Male Middle Aged Prognosis Radioimmunoassay Renin / blood* Retrospective Studies Time Factors |
| Chemical | |
Reg. No./Substance:
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52-39-1/Aldosterone; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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