Document Detail

High-performance self-expanding stent graft: development and application to experimental aneurysms.
MedLine Citation:
PMID:  19330503     Owner:  NLM     Status:  MEDLINE    
Large or giant aneurysms in the craniocervical area with broad necks are of concern and are treated surgically, endovascularly, or in both ways. Surgically, their treatment is difficult, with relatively high risks. For their embolization, we have been developing a high-performance stent graft that has three characteristics: a thin and expandable segmented polyurethane (SPU) membrane, micropores formed by the excimer laser ablation technique, and a drug delivery system at the membrane. Stent grafts were fabricated using commercially available self-expanding stents. These stents were covered with a thin SPU membrane by the dip-coating method. Micropores were then formed by the excimer laser ablation technique and an argatroban coating was added. We tested the effectiveness of this new stent graft by treating experimental canine aneurysms. Experimental aneurysms were made in the bilateral carotid arteries of four female beagles by end-to-side anastomosis using an autologous venous pouch. One month after aneurysm formation, the experimental aneurysm in one of the carotid arteries was covered with our self-expanding stent graft and the aneurysm in the other artery was covered with a bare self-expanding stent. On angiograms 1 month after stenting, the aneurysms treated with our stent graft were completely occluded without significant parent artery stenosis, but the aneurysms treated with the original bare stent were still open. Our high-performance self-expanding stent graft was easily applied to the experimental aneurysms and accomplished complete occlusion of aneurysms in beagles. Further study should be performed for the goal of clinical use.
Shogo Nishi; Yasuhide Nakayama; Hatsue Ishibashi-Ueda; Yoshihiro Okamoto; Yusuke Kinoshita
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Publication Detail:
Type:  Journal Article     Date:  2009-03-29
Journal Detail:
Title:  Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs     Volume:  12     ISSN:  1619-0904     ISO Abbreviation:  J Artif Organs     Publication Date:  2009  
Date Detail:
Created Date:  2009-03-30     Completed Date:  2009-07-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815648     Medline TA:  J Artif Organs     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  35-9     Citation Subset:  IM    
Department of Neurosurgery, Interventional Neurosurgery, and Spinal Surgery, Sapporo Higashi-Tokushukai Hospital, 14-3-1 Higashi, Higashi-ku, Sapporo, Japan.
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MeSH Terms
Aneurysm / pathology,  radiography,  surgery*
Carotid Arteries / pathology
Carotid Artery Diseases / pathology,  radiography,  surgery*
Drug-Eluting Stents*
Prosthesis Design
Prosthesis Implantation*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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