Document Detail


High-performance liquid chromatography of biologically important, small epimeric peptides and their L, D-amino acid content.
MedLine Citation:
PMID:  20470244     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Since most of the proteinogenic alpha-amino acids contain a chiral carbon atom, the stereoisomers of both these amino acids and the peptides in which they are to be found may possess differences in biological activity in living systems. The important analytical task of the separation of optical isomers is achieved mainly by chromatographic methods. This special review surveys direct and indirect HPLC separations of biologically important, small epimeric peptides and their L, D-amino acid content.
Authors:
I Ilisz; Z Pataj; A Aranyi; A Péter
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Mini reviews in medicinal chemistry     Volume:  10     ISSN:  1875-5607     ISO Abbreviation:  Mini Rev Med Chem     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-05-17     Completed Date:  2010-09-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101094212     Medline TA:  Mini Rev Med Chem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  287-98     Citation Subset:  IM    
Affiliation:
Department of Inorganic and Analytical Chemistry, University of Szeged, H-6720 Szeged, Dóm tér 7, Hungary.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Amino Acids*
Animals
Biological Products / chemistry,  metabolism
Chromatography, High Pressure Liquid / methods*
Humans
Peptides / chemical synthesis,  chemistry*,  isolation & purification*,  metabolism
Stereoisomerism
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Biological Products; 0/Peptides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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