| High-performance liquid chromatographic separation and determination of the process related impurities of mebendazole, fenbendazole and albendazole in bulk drugs. | |
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MedLine Citation:
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PMID: 11600304 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Simple, specific and rapid reversed-phase high-performance liquid chromatographic methods to separate and determine potential impurities of anthelmintic drugs viz., mebendazole, fenbendazole and albendazole are reported. These methods afforded efficient separation, good resolution and identification of all the impurities examined. The methods were successfully applied not only for quality assurance, but also process development of the select anthelmintic drugs. |
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Authors:
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A R Gomes; V Nagaraju |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pharmaceutical and biomedical analysis Volume: 26 ISSN: 0731-7085 ISO Abbreviation: J Pharm Biomed Anal Publication Date: 2001 Dec |
Date Detail:
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Created Date: 2001-10-15 Completed Date: 2002-01-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8309336 Medline TA: J Pharm Biomed Anal Country: England |
Other Details:
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Languages: eng Pagination: 919-27 Citation Subset: IM |
Affiliation:
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Analytical Development Laboratory, Cipla Limited, 560 049, Bangalore, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Albendazole
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analysis* Chromatography, High Pressure Liquid Drug Contamination* Fenbendazole / analysis* Indicators and Reagents Mebendazole / analysis* Spectrophotometry, Ultraviolet |
| Chemical | |
Reg. No./Substance:
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0/Indicators and Reagents; 31431-39-7/Mebendazole; 43210-67-9/Fenbendazole; 54965-21-8/Albendazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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