| High-performance liquid chromatographic enantioseparation of 1-(aminoalkyl)-2-naphthol analogs on polysaccharide-based chiral stationary phases. | |
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MedLine Citation:
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PMID: 17380485 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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The enantiomers of various 1-(alpha-aminobenzyl)-2-naphthol and 1-(aminoalkyl)-2-naphthol analogs were separated on cellulose-tris-3,5-dimethylphenyl carbamate-based chiral stationary phases (Chiralcel OD-H and Chiralcel OD-RH), using n-hexane/2-propanol/diethylamine or phosphate buffer/organic modifier mobile phases. The 3,5-dimethylphenyl carbamoylated cellulose columns were effective in both normal and rev ersed-phase modes. The effects of the mobile phase composition, the pH, the buffer concentration, and the structures of the substituents on the 2-naphthol on the enantioseparations were studied. The absolute configuration and elution sequence were determined for 1-(1-amino-2-methylpropyl)-2-naphthol: the elution sequence was S < R. |
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Authors:
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Anita Sztojkov-Ivanov; Diana Tóth; István Szatmári; Ferenc Fülöp; Antal Péter |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chirality Volume: 19 ISSN: 0899-0042 ISO Abbreviation: Chirality Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-04-11 Completed Date: 2007-05-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8914261 Medline TA: Chirality Country: United States |
Other Details:
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Languages: eng Pagination: 374-9 Citation Subset: - |
Affiliation:
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Institute of Pharmaceutical Chemistry, University of Szeged, H-6720 Szeged, Eötvös u. 6, Hungary. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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