| High-performance liquid chromatographic analysis of basic compounds on non-modified silica gel and aluminium oxide with aqueous solvent mixtures. | |
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MedLine Citation:
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PMID: 3009508 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A comparison is made between the use of aluminium oxide and non-modified silica gel as cation-exchange materials for the separation of basic drugs (amines) with aqueous solvent mixtures. The retention behaviour of the amines is studied and appears to be controlled predominantly by the pH and the concentration and nature of the modifier; the nature and concentration of the competing ions and the buffer components of the mobile phase also exert some influence on the retention. Preparations with imidazoline and tetracycline derivatives have been analysed as examples of the application of these ion-exchange systems on non-modified silica gel and aluminium oxide in the analysis of pharmaceutical formulations. |
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Authors:
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H Lingeman; H A van Munster; J H Beynen; W J Underberg; A Hulshoff |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of chromatography Volume: 352 ISSN: 0021-9673 ISO Abbreviation: J. Chromatogr. Publication Date: 1986 Feb |
Date Detail:
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Created Date: 1986-06-25 Completed Date: 1986-06-25 Revised Date: 2000-12-18 |
Medline Journal Info:
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Nlm Unique ID: 0427043 Medline TA: J Chromatogr Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 261-74 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aluminum Oxide Amines / analysis Chromatography, High Pressure Liquid Hydrogen-Ion Concentration Imidazoles / analysis Pharmaceutical Preparations / analysis* Silicon Dioxide Solvents Tetracyclines / analysis |
| Chemical | |
Reg. No./Substance:
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0/Amines; 0/Imidazoles; 0/Pharmaceutical Preparations; 0/Solvents; 0/Tetracyclines; 1344-28-1/Aluminum Oxide; 526-36-3/xylometazoline; 60650-90-0/silochrome; 7631-86-9/Silicon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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