Document Detail


High-performance liquid chromatographic analysis of basic compounds on non-modified silica gel and aluminium oxide with aqueous solvent mixtures.
MedLine Citation:
PMID:  3009508     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A comparison is made between the use of aluminium oxide and non-modified silica gel as cation-exchange materials for the separation of basic drugs (amines) with aqueous solvent mixtures. The retention behaviour of the amines is studied and appears to be controlled predominantly by the pH and the concentration and nature of the modifier; the nature and concentration of the competing ions and the buffer components of the mobile phase also exert some influence on the retention. Preparations with imidazoline and tetracycline derivatives have been analysed as examples of the application of these ion-exchange systems on non-modified silica gel and aluminium oxide in the analysis of pharmaceutical formulations.
Authors:
H Lingeman; H A van Munster; J H Beynen; W J Underberg; A Hulshoff
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of chromatography     Volume:  352     ISSN:  -     ISO Abbreviation:  J. Chromatogr.     Publication Date:  1986 Feb 
Date Detail:
Created Date:  1986-06-25     Completed Date:  1986-06-25     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  0427043     Medline TA:  J Chromatogr     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  261-74     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aluminum Oxide
Amines / analysis
Chromatography, High Pressure Liquid
Hydrogen-Ion Concentration
Imidazoles / analysis
Pharmaceutical Preparations / analysis*
Silica Gel
Silicon Dioxide
Solvents
Tetracyclines / analysis
Chemical
Reg. No./Substance:
0/Amines; 0/Imidazoles; 0/Pharmaceutical Preparations; 0/Solvents; 0/Tetracyclines; 60650-90-0/Silica Gel; 7631-86-9/Silicon Dioxide; LMI26O6933/Aluminum Oxide; WPY40FTH8K/xylometazoline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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