Document Detail

High parathyroid hormone, but not low vitamin D concentrations, expose elderly inpatients to hypertension.
MedLine Citation:
PMID:  22994947     Owner:  NLM     Status:  Publisher    
Aim:  Serum parathyroid hormone (PTH) and 25-hydroxyvitamin D (25OHD) concentrations might contribute to blood pressure (BP) levels. Mixed results in previous literature could be due to the failure to consider both these hormones concurrently, despite their long-known relationship. Our objective was to examine the association of serum intact PTH and 25OHD concentrations with BP levels amongst older inpatients, while accounting for each other. Methods:  The participants were 284 Caucasian older inpatients with no suspicion of primary hyperparathyroidism (mean age 85.87 ± 5.90 years; 65.8% female) admitted to the geriatric acute care unit of Angers University Hospital, France. They were divided into two groups according to the existence of hypertension (i.e. systolic blood pressure [SBP] >140 mmHg, or diastolic blood pressure [DBP] >90 mmHg). Age, sex, numbers of chronic diseases and of drugs taken daily, use of antihypertensive or corticosteroid drugs and of calcium supplements/vitamin D, thyroid-stimulating hormone and albumin concentrations, creatinine clearance, and season tested were used as covariables. Results:  Hypertensive participants (n = 106) had higher intact PTH concentrations than normotensive patients (P = 0.044). There was a positive linear association of BP with intact PTH concentrations (adjusted β = 0.08, P = 0.015 for SBP; adjusted β = 0.05, P = 0.044 for DBP), but not with vitamin D. Serum intact PTH concentration, unlike 25OHD, was associated with hypertension (adjusted OR 1.01, P = 0.038). Conclusions:  Irrespective of 25OHD, PTH was associated with hypertension by increasing both SBP and DBP. Geriatr Gerontol Int 2012; ••: ••-••.
Leyla Mateus-Hamdan; Olivier Beauchet; Béatrice Bouvard; Erick Legrand; Bruno Fantino; Cédric Annweiler
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-19
Journal Detail:
Title:  Geriatrics & gerontology international     Volume:  -     ISSN:  1447-0594     ISO Abbreviation:  Geriatr Gerontol Int     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101135738     Medline TA:  Geriatr Gerontol Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Japan Geriatrics Society.
Departments of Neuroscience, Division of Geriatric Medicine Rheumatology, Angers University Hospital Angers University Memory Clinic UPRES EA 2646 University of Angers, UNAM, Angers Health Examination Center, CNAMTS, Lyon, France Department of Medicine, Division of Geriatric Medicine, Parkwood Hospital, St. Joseph's Health Care London Gait and Brain Lab, Lawson Health Research Institute, Western University, London, Ontario, Canada.
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