| High omega-6 and low omega-3 fatty acids are associated with depressive symptoms and neuroticism. | |
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MedLine Citation:
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PMID: 17991818 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To examine the concentrations of omega-3 and omega-6 polyunsaturated fatty acids in serum obtained from nonpatient community volunteers not selected for hypercholesterolemia. Previously we reported that the relative concentrations of omega-3 and omega-6 polyunsaturated fatty acids in serum covary with depressive symptomatology and neuroticism in hypercholesterolemic adults. METHODS: A total of 116 adults without current Axis I psychopathology completed the Beck Depression Inventory (BDI) and the NEO Personality Inventory--Revised (NEO-PI-R). Fasting serum phospholipid eicosapentaenoic (EPA), docosahexaenoic (DHA), and arachidonic acid (AA) were determined (% of total pool). RESULTS: Higher AA and AA:EPA ratio, adjusted for age, gender, and race, were associated with greater depressive symptomatology (BDI score of >or=10). Lower EPA, and higher AA, AA:EPA ratio and AA:DHA ratio were associated with greater NEO-PI-R Neuroticism. The six Neuroticism subscales were each associated with two or more fatty acid measurements. CONCLUSIONS: In conjunction with other reports, these findings suggest that the omega-3 and omega-6 fatty acids are related to negative affect at both the symptom and trait levels. |
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Authors:
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Sarah M Conklin; Stephen B Manuck; Jeffrey K Yao; Janine D Flory; Joseph R Hibbeln; Matthew F Muldoon |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2007-11-08 |
Journal Detail:
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Title: Psychosomatic medicine Volume: 69 ISSN: 1534-7796 ISO Abbreviation: Psychosom Med Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-11-27 Completed Date: 2007-12-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376505 Medline TA: Psychosom Med Country: United States |
Other Details:
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Languages: eng Pagination: 932-4 Citation Subset: IM |
Affiliation:
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Department of Psychology, Allegheny College, 520 North Main Street, Meadville, PA 16335-3902, USA. Sarah.Conklin@allegheny.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arachidonic Acid / blood Body Mass Index Depression / blood*, psychology Docosahexaenoic Acids / blood Eicosapentaenoic Acid / blood Fatty Acids, Omega-3 / blood* Fatty Acids, Omega-6 / blood* Female Humans Hypercholesterolemia / blood Male Middle Aged Neurotic Disorders / blood*, psychology Personality Inventory Reference Values Regression Analysis Statistics as Topic Triglycerides / blood |
| Grant Support | |
ID/Acronym/Agency:
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P01 HL040962/HL/NHLBI NIH HHS; R21 HL081282/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; 0/Triglycerides; 1553-41-9/Eicosapentaenoic Acid; 25167-62-8/Docosahexaenoic Acids; 506-32-1/Arachidonic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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