Document Detail

High omega-6 and low omega-3 fatty acids are associated with depressive symptoms and neuroticism.
MedLine Citation:
PMID:  17991818     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the concentrations of omega-3 and omega-6 polyunsaturated fatty acids in serum obtained from nonpatient community volunteers not selected for hypercholesterolemia. Previously we reported that the relative concentrations of omega-3 and omega-6 polyunsaturated fatty acids in serum covary with depressive symptomatology and neuroticism in hypercholesterolemic adults. METHODS: A total of 116 adults without current Axis I psychopathology completed the Beck Depression Inventory (BDI) and the NEO Personality Inventory--Revised (NEO-PI-R). Fasting serum phospholipid eicosapentaenoic (EPA), docosahexaenoic (DHA), and arachidonic acid (AA) were determined (% of total pool). RESULTS: Higher AA and AA:EPA ratio, adjusted for age, gender, and race, were associated with greater depressive symptomatology (BDI score of >or=10). Lower EPA, and higher AA, AA:EPA ratio and AA:DHA ratio were associated with greater NEO-PI-R Neuroticism. The six Neuroticism subscales were each associated with two or more fatty acid measurements. CONCLUSIONS: In conjunction with other reports, these findings suggest that the omega-3 and omega-6 fatty acids are related to negative affect at both the symptom and trait levels.
Sarah M Conklin; Stephen B Manuck; Jeffrey K Yao; Janine D Flory; Joseph R Hibbeln; Matthew F Muldoon
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2007-11-08
Journal Detail:
Title:  Psychosomatic medicine     Volume:  69     ISSN:  1534-7796     ISO Abbreviation:  Psychosom Med     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-27     Completed Date:  2007-12-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376505     Medline TA:  Psychosom Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  932-4     Citation Subset:  IM    
Department of Psychology, Allegheny College, 520 North Main Street, Meadville, PA 16335-3902, USA.
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MeSH Terms
Arachidonic Acid / blood
Body Mass Index
Depression / blood*,  psychology
Docosahexaenoic Acids / blood
Eicosapentaenoic Acid / blood
Fatty Acids, Omega-3 / blood*
Fatty Acids, Omega-6 / blood*
Hypercholesterolemia / blood
Middle Aged
Neurotic Disorders / blood*,  psychology
Personality Inventory
Reference Values
Regression Analysis
Statistics as Topic
Triglycerides / blood
Grant Support
Reg. No./Substance:
0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; 0/Triglycerides; 1553-41-9/Eicosapentaenoic Acid; 25167-62-8/Docosahexaenoic Acids; 506-32-1/Arachidonic Acid

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