| High-normal blood pressure and early diabetic nephropathy. | |
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MedLine Citation:
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PMID: 2310283 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The relationship between high-normal blood pressure (BP) levels and early diabetic nephropathy is currently unknown. Blood pressure levels were checked longitudinally for a mean of 6.6 years in 230 subjects to determine their relationship to early diabetic nephropathy as monitored by microalbuminuria. High-normal BP level correlated with the presence of microalbuminuria. Microalbuminuria was 2.8 times as common in subjects with high-normal BP levels compared with those subjects with BP levels below the 90th percentile for their age. The elevated microalbumin excretion was primarily associated with high-normal diastolic BP levels. Our data suggest that either microalbuminuria or high-normal BP levels can precede the other. In a logistics model, diastolic BP and mean HbA1 (over 6.6 years) entered the model at similar levels, followed by duration of diabetes. When the influence of mean HbA1 was removed using logistic regression, the diastolic BP level remained a significant associated factor for the presence of microalbuminuria. |
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Authors:
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H P Chase; S K Garg; S Harris; S L Hoops; G Marshall |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Archives of internal medicine Volume: 150 ISSN: 0003-9926 ISO Abbreviation: Arch. Intern. Med. Publication Date: 1990 Mar |
Date Detail:
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Created Date: 1990-04-06 Completed Date: 1990-04-06 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372440 Medline TA: Arch Intern Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 639-41 Citation Subset: AIM; IM |
Affiliation:
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Barbara Davis Center for Childhood Diabetes, Department of Pediatrics, University of Colorado Health Science Center, Denver 80262. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Albuminuria / diagnosis, physiopathology* Blood Pressure* Diabetic Nephropathies / diagnosis, physiopathology* Female Humans Logistic Models Male Reference Values Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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RR69/RR/NCRR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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